Protein Tyrosine Phosphatase Receptor Type B (PTPRB)

PTPR-B; HPTP-Beta; HPTPB; PTPB; VE-PTP; R-PTP-Beta; Protein-tyrosine phosphatase beta; Vascular endothelial protein tyrosine phosphatase

SPN	V764
HGNC	9665
MGI	97809
PubMed	18361428
RGD	1305922
UniProt	P23467
Wiki	PTPRB

Receptor-type tyrosine-protein phosphatase beta isa member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status.

Reference

"Structural diversity and evolution of human receptor-like protein tyrosine phosphatases."
EMBO J. 9:3241-3252(1990) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

"Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells."
Angiogenesis 12:25-33(2009) [PubMed] [Europe PMC] [Abstract]

"Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis."
FASEB J. 23:1490-1502(2009) [PubMed] [Europe PMC] [Abstract]

"VE-PTP controls blood vessel development by balancing Tie-2 activity."
J. Cell Biol. 185:657-671(2009) [PubMed] [Europe PMC] [Abstract]

"Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery."
Acta Crystallogr. D 62:1435-1445(2006) [PubMed] [Europe PMC] [Abstract]

"Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta."
Bioorg. Med. Chem. Lett. 16:4252-4256(2006) [PubMed] [Europe PMC] [Abstract]

"Large-scale structural analysis of the classical human protein tyrosine phosphatome."
Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]