Trefoil Factor 1 (TFF1)

BCEI; HP1.A; HPS2; PS2; PNR2; Breast Cancer,Estrogen-Inducible Sequence Expressed In; Breast cancer estrogen-inducible protein; Polypeptide P1.A

SPN	V763
HGNC	11755
MGI	88135
PubMed	21747314
RGD	620707
UniProt	P04155
Wiki	TFF1

Trefoil factor 1 is a protein that is encoded by the TFF1 gene. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium.

Trefoil factor 1, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Reference

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Nucleic Acids Res. 15:1401-1414(1987) [PubMed] [Europe PMC] [Abstract]

"Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma."
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"Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP-C."
Biochemistry 44:7967-7975(2005) [PubMed] [Europe PMC] [Abstract]

"Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor."
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"Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product."
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"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
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"Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa."
Science 241:705-708(1988) [PubMed] [Europe PMC] [Abstract]

"Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer."
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"Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues."
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"Tissue localization of human trefoil factors 1, 2, and 3."
J. Histochem. Cytochem. 55:505-513(2007) [PubMed] [Europe PMC] [Abstract]

"NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide. Similarities to porcine spasmolytic peptide and evidence for a monomeric structure."
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"High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein."
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"Somatic mutations of the trefoil factor family 1 gene in gastric cancer."
Gastroenterology 119:691-698(2000) [PubMed] [Europe PMC] [Abstract]

"Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways."
Gastroenterology 130:1696-1706(2006) [PubMed] [Europe PMC] [Abstract]