Apoptosis Inducing Factor (AIF)
PDCD8; Programmed Cell Death protein 8; Apoptosis-inducing factor 1, mitochondrial
Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the mitochondrial membrane upon apoptosis.
Normally it is found behind the outer membrane of the mitochondria and is therefore secluded from the nucleus. However, when the mitochondria is damaged, it moves to the cytosol and to the nucleus.
Inactivation of AIF leads to resistance of embryonic stem cells to death following the withdrawal of growth factors indicating that it is involved in apoptosis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV748Hu01 | Recombinant Apoptosis Inducing Factor (AIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV748Hu01 | Monoclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IP. |
| PAV748Hu01 | Polyclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV748Hu01 | CLIA Kit for Apoptosis Inducing Factor (AIF) | CLIA assay for Antigen Detection |
| ELV748Hu01 | ELISA Kit for Apoptosis Inducing Factor (AIF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV748Mu01 | Recombinant Apoptosis Inducing Factor (AIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV748Mu01 | Monoclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IP. |
| PAV748Mu01 | Polyclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV748Mu01 | CLIA Kit for Apoptosis Inducing Factor (AIF) | CLIA assay for Antigen Detection |
| ELV748Mu01 | ELISA Kit for Apoptosis Inducing Factor (AIF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV748Ra01 | Recombinant Apoptosis Inducing Factor (AIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV748Ra01 | Monoclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IP. |
| PAV748Ra01 | Polyclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV748Ra01 | CLIA Kit for Apoptosis Inducing Factor (AIF) | CLIA assay for Antigen Detection |
| ELV748Ra01 | ELISA Kit for Apoptosis Inducing Factor (AIF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV748Ca01 | Recombinant Apoptosis Inducing Factor (AIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV748Ca01 | Monoclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IP. |
| PAV748Ca01 | Polyclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV748Ca01 | CLIA Kit for Apoptosis Inducing Factor (AIF) | CLIA assay for Antigen Detection |
| ELV748Ca01 | ELISA Kit for Apoptosis Inducing Factor (AIF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV748Po01 | Recombinant Apoptosis Inducing Factor (AIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV748Po01 | Monoclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IP. |
| PAV748Po01 | Polyclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV748Po01 | CLIA Kit for Apoptosis Inducing Factor (AIF) | CLIA assay for Antigen Detection |
| ELV748Po01 | ELISA Kit for Apoptosis Inducing Factor (AIF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV748Bo01 | Recombinant Apoptosis Inducing Factor (AIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV748Bo01 | Monoclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IP. |
| PAV748Bo01 | Polyclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV748Bo01 | CLIA Kit for Apoptosis Inducing Factor (AIF) | CLIA assay for Antigen Detection |
| ELV748Bo01 | ELISA Kit for Apoptosis Inducing Factor (AIF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV748Rb01 | Recombinant Apoptosis Inducing Factor (AIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV748Rb01 | Monoclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IP. |
| PAV748Rb01 | Polyclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV748Rb01 | CLIA Kit for Apoptosis Inducing Factor (AIF) | CLIA assay for Antigen Detection |
| ELV748Rb01 | ELISA Kit for Apoptosis Inducing Factor (AIF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV748Mo01 | Recombinant Apoptosis Inducing Factor (AIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV748Mo01 | Monoclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IP. |
| PAV748Mo01 | Polyclonal Antibody to Apoptosis Inducing Factor (AIF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV748Mo01 | CLIA Kit for Apoptosis Inducing Factor (AIF) | CLIA assay for Antigen Detection |
| ELV748Mo01 | ELISA Kit for Apoptosis Inducing Factor (AIF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular characterization of mitochondrial apoptosis-inducing factor."
Nature 397:441-446(1999) [PubMed] [Europe PMC] [Abstract]
"AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer."
J. Biol. Chem. 281:6413-6427(2006) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activity."
J. Biol. Chem. 281:18507-18518(2006) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space."
EMBO J. 24:1375-1386(2005) [PubMed] [Europe PMC] [Abstract]
"Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis."
FEBS Lett. 476:118-123(2000) [PubMed] [Europe PMC] [Abstract]
"Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g)."
FEBS Lett. 580:6375-6383(2006) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP."
Mol. Cell. Biol. 28:237-247(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Apoptosis-inducing factor plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells."
Apoptosis 14:796-808(2009) [PubMed] [Europe PMC] [Abstract]
"A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2."
Cell Death Differ. 17:1155-1166(2010) [PubMed] [Europe PMC] [Abstract]
"Vital function of PRELI and essential requirement of its LEA motif."
Cell Death Dis. 1:E21-E21(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation."
Biochemistry 50:11084-11096(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"DNA binding is required for the apoptogenic action of apoptosis inducing factor."
Nat. Struct. Biol. 9:680-684(2002) [PubMed] [Europe PMC] [Abstract]
"Cowchock syndrome is associated with a mutation in apoptosis-inducing factor."
Am. J. Hum. Genet. 91:1095-1102(2012) [PubMed] [Europe PMC] [Abstract]
"Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor."
Am. J. Hum. Genet. 86:639-649(2010) [PubMed] [Europe PMC] [Abstract]
"Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing."
Mol. Genet. Metab. 104:517-520(2011) [PubMed] [Europe PMC] [Abstract]
"From ventriculomegaly to severe muscular atrophy: Expansion of the clinical spectrum related to mutations in AIFM1."
Mitochondrion 21C:12-18(2015) [PubMed] [Europe PMC] [Abstract]