Dopachrome Tautomerase (DCT)
TYRP2; TRP-2; DT; Dopachrome Delta-Isomerase; Tyrosine-Related Protein 2; L-dopachrome Delta-isomerase
Dopachrome tautomerase , also known as DCT, is an enzyme that isomerizes the melanogenic intermediate 3,4-dihydroxyphenylalanine-chrome (DOPAchrome) to 5,6-dihydroxyindole-2-carboxylic acid (DHICA) in the biosynthesis of melanin. Its expression is regulated by the Microphthalmia-associated transcription factor.
human TYRP2 protein has 83% identity and 90% similarity to the mouse sequence and has all the structural characteristics of the tyrosinase protein family, including a signal peptide, 15 conserved cysteine residues, 2 copper-binding domains, and a C-terminal membrane-spanning region. Northern blot analysis showed that TYRP2 is expressed at high levels in human melanoma cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV746Hu01 | Recombinant Dopachrome Tautomerase (DCT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV746Hu01 | Monoclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IP. |
| PAV746Hu01 | Polyclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV746Hu01 | CLIA Kit for Dopachrome Tautomerase (DCT) | CLIA assay for Antigen Detection |
| ELV746Hu01 | ELISA Kit for Dopachrome Tautomerase (DCT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV746Mu01 | Recombinant Dopachrome Tautomerase (DCT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV746Mu01 | Monoclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IP. |
| PAV746Mu01 | Polyclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV746Mu01 | CLIA Kit for Dopachrome Tautomerase (DCT) | CLIA assay for Antigen Detection |
| ELV746Mu01 | ELISA Kit for Dopachrome Tautomerase (DCT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV746Ra01 | Recombinant Dopachrome Tautomerase (DCT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV746Ra01 | Monoclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IP. |
| PAV746Ra01 | Polyclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV746Ra01 | CLIA Kit for Dopachrome Tautomerase (DCT) | CLIA assay for Antigen Detection |
| ELV746Ra01 | ELISA Kit for Dopachrome Tautomerase (DCT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV746Ca01 | Recombinant Dopachrome Tautomerase (DCT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV746Ca01 | Monoclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IP. |
| PAV746Ca01 | Polyclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV746Ca01 | CLIA Kit for Dopachrome Tautomerase (DCT) | CLIA assay for Antigen Detection |
| ELV746Ca01 | ELISA Kit for Dopachrome Tautomerase (DCT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV746Po01 | Recombinant Dopachrome Tautomerase (DCT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV746Po01 | Monoclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IP. |
| PAV746Po01 | Polyclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV746Po01 | CLIA Kit for Dopachrome Tautomerase (DCT) | CLIA assay for Antigen Detection |
| ELV746Po01 | ELISA Kit for Dopachrome Tautomerase (DCT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV746Bo01 | Recombinant Dopachrome Tautomerase (DCT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV746Bo01 | Monoclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IP. |
| PAV746Bo01 | Polyclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV746Bo01 | CLIA Kit for Dopachrome Tautomerase (DCT) | CLIA assay for Antigen Detection |
| ELV746Bo01 | ELISA Kit for Dopachrome Tautomerase (DCT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV746Rb01 | Recombinant Dopachrome Tautomerase (DCT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV746Rb01 | Monoclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IP. |
| PAV746Rb01 | Polyclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV746Rb01 | CLIA Kit for Dopachrome Tautomerase (DCT) | CLIA assay for Antigen Detection |
| ELV746Rb01 | ELISA Kit for Dopachrome Tautomerase (DCT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV746Mo01 | Recombinant Dopachrome Tautomerase (DCT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV746Mo01 | Monoclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IP. |
| PAV746Mo01 | Polyclonal Antibody to Dopachrome Tautomerase (DCT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV746Mo01 | CLIA Kit for Dopachrome Tautomerase (DCT) | CLIA assay for Antigen Detection |
| ELV746Mo01 | ELISA Kit for Dopachrome Tautomerase (DCT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2."
Biochim. Biophys. Acta 1217:317-321(1994) [PubMed] [Europe PMC] [Abstract]
"Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA."
Gene 143:295-298(1994) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells."
Eur. J. Biochem. 219:127-134(1994) [PubMed] [Europe PMC] [Abstract]
"Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy."
J. Immunol. 168:951-956(2002) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family."
Genomics 29:24-34(1995) [PubMed] [Europe PMC] [Abstract]
"Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression."
J. Biol. Chem. 269:27080-27087(1994) [PubMed] [Europe PMC] [Abstract]
"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]