S100 Calcium Binding Protein A13 (S100A13)

S100-A13

SPN	V735
HGNC	10490
MGI	109581
PubMed	20863990
RGD	1304919
UniProt	Q99584
Wiki	S100A13

Protein S100-A13, a protein protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Reference

"Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family."
Biochem. Biophys. Res. Commun. 227:594-599(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells."
J. Cell Sci. 116:2687-2696(2003) [PubMed] [Europe PMC] [Abstract]

"Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells."
J. Formos. Med. Assoc. 109:632-640(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Structural interplay between calcium(II) and copper(II) binding to S100A13 protein."
Angew. Chem. Int. Ed. 44:6341-6344(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structure study on human S100A13 at 2.0 A resolution."
Biochem. Biophys. Res. Commun. 356:616-621(2007) [PubMed] [Europe PMC] [Abstract]

"Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution."
Acta Crystallogr. F 64:70-76(2008) [PubMed] [Europe PMC] [Abstract]

"S100A13-C2A binary complex structure-a key component in the acidic fibroblast growth factor for the non-classical pathway."
Biochem. Biophys. Res. Commun. 380:514-519(2009) [PubMed] [Europe PMC] [Abstract]