General Transcription Factor IIH, Polypeptide 1 (GTF2H1)

GTF2-H1; BTF2; TFIIH; BTF2 p62; Basic transcription factor 2 62 kDa subunit; TFIIH basal transcription factor complex p62 subunit

SPN	V734
HGNC	4655
MGI	1277216
PubMed	18692935
RGD	1308225
UniProt	P32780
Wiki	GTF2H1

Transcription factor II H (TFIIH) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIH consists of ten subunits, 7 of which (XPD, XPB, p62, p52, p44, p34 and TTDA) form the corecomplex. The cyclin activating kinase-subcomplex (CDK7, MAT1, and cyclin H) is linked to the core via the XPD protein. Two of the subunits, ERCC2/XPD and ERCC3/XPB, have helicase and ATPase activities and help create the transcription bubble. In a test tube these subunits are only required for transcription if the DNA template is not already denatured or if it is supercoiled. Two other TFIIH subunits, CDK7 and cyclin H, phosphorylate serine amino acids on the RNA polymerase II C-terminal domain and possibly other proteins involved in the cell cycle.

Reference

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Science 257:1392-1395(1992) [PubMed] [Europe PMC] [Abstract]

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J. Biol. Chem. 273:34444-34453(1998) [PubMed] [Europe PMC] [Abstract]

"The FBP interacting repressor targets TFIIH to inhibit activated transcription."
Mol. Cell 5:331-341(2000) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
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"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the BSD domain of human TFIIH basal transcription factor complex p62 subunit."
Submitted (SEP-2006) to the PDB data bank