Actinin Alpha 3 (ACTN3)
Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein
Actinin, alpha 3, also known as ACTN3, is a protein which in humans is encoded by the ACTN3 gene.Alpha-actinin is an actin-binding protein with multiple roles in different cell types. This gene expression is limited to skeletal muscle. It is localized to the Z-disc and analogous dense bodies, where it helps to anchor the myofibrillar actin filaments.
Skeletal muscle is composed of long cylindrical cells called muscle fibers. There are two types of muscle fibers, slow twitch or muscle contraction (type I) and fast twitch (type II). Slow twitch fibers are more efficient in using oxygen to generate energy whilst fast twitch fibers are less efficient. However, fast twitch fibers fire more rapidly and generate more force.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV709Hu01 | Recombinant Actinin Alpha 3 (ACTN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV709Hu01 | Monoclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IP. |
| PAV709Hu01 | Polyclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV709Hu01 | CLIA Kit for Actinin Alpha 3 (ACTN3) | CLIA assay for Antigen Detection |
| ELV709Hu01 | ELISA Kit for Actinin Alpha 3 (ACTN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV709Mu01 | Recombinant Actinin Alpha 3 (ACTN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV709Mu01 | Monoclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IP. |
| PAV709Mu01 | Polyclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV709Mu01 | CLIA Kit for Actinin Alpha 3 (ACTN3) | CLIA assay for Antigen Detection |
| ELV709Mu01 | ELISA Kit for Actinin Alpha 3 (ACTN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV709Ra01 | Recombinant Actinin Alpha 3 (ACTN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV709Ra01 | Monoclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IP. |
| PAV709Ra01 | Polyclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV709Ra01 | CLIA Kit for Actinin Alpha 3 (ACTN3) | CLIA assay for Antigen Detection |
| ELV709Ra01 | ELISA Kit for Actinin Alpha 3 (ACTN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV709Ca01 | Recombinant Actinin Alpha 3 (ACTN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV709Ca01 | Monoclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IP. |
| PAV709Ca01 | Polyclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV709Ca01 | CLIA Kit for Actinin Alpha 3 (ACTN3) | CLIA assay for Antigen Detection |
| ELV709Ca01 | ELISA Kit for Actinin Alpha 3 (ACTN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV709Po01 | Recombinant Actinin Alpha 3 (ACTN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV709Po01 | Monoclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IP. |
| PAV709Po01 | Polyclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV709Po01 | CLIA Kit for Actinin Alpha 3 (ACTN3) | CLIA assay for Antigen Detection |
| ELV709Po01 | ELISA Kit for Actinin Alpha 3 (ACTN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV709Bo01 | Recombinant Actinin Alpha 3 (ACTN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV709Bo01 | Monoclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IP. |
| PAV709Bo01 | Polyclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV709Bo01 | CLIA Kit for Actinin Alpha 3 (ACTN3) | CLIA assay for Antigen Detection |
| ELV709Bo01 | ELISA Kit for Actinin Alpha 3 (ACTN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV709Rb01 | Recombinant Actinin Alpha 3 (ACTN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV709Rb01 | Monoclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IP. |
| PAV709Rb01 | Polyclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV709Rb01 | CLIA Kit for Actinin Alpha 3 (ACTN3) | CLIA assay for Antigen Detection |
| ELV709Rb01 | ELISA Kit for Actinin Alpha 3 (ACTN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV709Mo01 | Recombinant Actinin Alpha 3 (ACTN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV709Mo01 | Monoclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IP. |
| PAV709Mo01 | Polyclonal Antibody to Actinin Alpha 3 (ACTN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV709Mo01 | CLIA Kit for Actinin Alpha 3 (ACTN3) | CLIA assay for Antigen Detection |
| ELV709Mo01 | ELISA Kit for Actinin Alpha 3 (ACTN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11."
J. Biol. Chem. 267:9281-9288(1992) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy."
Hum. Mol. Genet. 10:1335-1346(2001) [PubMed] [Europe PMC] [Abstract]
"Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines."
Proc. Natl. Acad. Sci. U.S.A. 98:1595-1600(2001) [PubMed] [Europe PMC] [Abstract]
"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of the actin binding domain from alpha-actinin in its closed conformation: structural insight into phospholipid regulation of alpha-actinin."
J. Mol. Biol. 348:151-165(2005) [PubMed] [Europe PMC] [Abstract]
"A common nonsense mutation results in alpha-actinin-3 deficiency in the general population."
Nat. Genet. 21:353-354(1999) [PubMed] [Europe PMC] [Abstract]