Myosin Light Chain 1, Alkali, Fast Skeletal (MYL1)

MLC1; MLC1F; MLC3F; Myosin light chain 1/3, skeletal muscle isoform; Myosin light chain A1/A2

SPN	V708
HGNC	7582
MGI	97269
PubMed	21674687
UniProt	P06741
Wiki	MYL1

In vertebrate striated muscle, myosin is composed of 2 heavy chains of about 200,000 daltons each and 4 light chains of about 20,000 daltons each. The light chains are of 2 distinct types: the phosphorylatable, regulatory, or MLC2 type, and the nonphosphorylatable, alkali, or MLC1 and MLC3 types (MYL1 according to the HGM symbols). The previously uncharacterized zebrafish alkali-like myosin light chain gene (myl1) was found to be expressed exclusively in cells in the fast-twitch pathway initiated at an early stage of fast fibre differentiation. Myl1 was expressed earlier, and in a more fibre type restricted manner, than any of the previously described and frequently used fast myosin light and heavy chain and troponin muscle markers mylz2, mylz3, tnni2, tnnt3a, fMyHC1.3.

Reference

"The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3."
Nucleic Acids Res. 15:4989-4989(1987) [PubMed] [Europe PMC] [Abstract]

"Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms."
Gene 66:135-146(1988) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle."
J. Biol. Chem. 264:16109-16117(1989) [PubMed] [Europe PMC] [Abstract]