Arginase (ARG)
ARG1; Arginase I; Liver Arginase
Arginase is the fifth and final step in the urea cycle, a series of biophysical reactions in mammals during which the body disposes of harmful ammonia. Specifically, arginase converts L-arginine into L-ornithine and urea. In most mammals, two isozymes of this enzyme exist; the first, Arginase I, functions in the urea cycle, and is located primarily in the cytoplasm of the liver. The second isozyme, Arginase II, has been implicated in the regulation of the arginine/ornithine concentrations in the cell. It is located in mitochondria of several tissues in the body, with most abundance in the kidney and prostate. It may be found at lower levels in macrophages, lactating mammary glands, and brain. The second isozyme may be found in the absence of other urea cycle enzymes. Arginase consists of three tetramers.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV693Hu01 | Recombinant Arginase (ARG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV693Hu01 | Monoclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IP. |
| PAV693Hu01 | Polyclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV693Hu01 | CLIA Kit for Arginase (ARG) | CLIA assay for Antigen Detection |
| ELV693Hu01 | ELISA Kit for Arginase (ARG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV693Mu01 | Recombinant Arginase (ARG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV693Mu01 | Monoclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IP. |
| PAV693Mu01 | Polyclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV693Mu01 | CLIA Kit for Arginase (ARG) | CLIA assay for Antigen Detection |
| ELV693Mu01 | ELISA Kit for Arginase (ARG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV693Ra01 | Recombinant Arginase (ARG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV693Ra01 | Monoclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IP. |
| PAV693Ra01 | Polyclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV693Ra01 | CLIA Kit for Arginase (ARG) | CLIA assay for Antigen Detection |
| ELV693Ra01 | ELISA Kit for Arginase (ARG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV693Ca01 | Recombinant Arginase (ARG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV693Ca01 | Monoclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IP. |
| PAV693Ca01 | Polyclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV693Ca01 | CLIA Kit for Arginase (ARG) | CLIA assay for Antigen Detection |
| ELV693Ca01 | ELISA Kit for Arginase (ARG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV693Po01 | Recombinant Arginase (ARG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV693Po01 | Monoclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IP. |
| PAV693Po01 | Polyclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV693Po01 | CLIA Kit for Arginase (ARG) | CLIA assay for Antigen Detection |
| ELV693Po01 | ELISA Kit for Arginase (ARG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV693Bo01 | Recombinant Arginase (ARG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV693Bo01 | Monoclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IP. |
| PAV693Bo01 | Polyclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV693Bo01 | CLIA Kit for Arginase (ARG) | CLIA assay for Antigen Detection |
| ELV693Bo01 | ELISA Kit for Arginase (ARG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV693Rb01 | Recombinant Arginase (ARG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV693Rb01 | Monoclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IP. |
| PAV693Rb01 | Polyclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV693Rb01 | CLIA Kit for Arginase (ARG) | CLIA assay for Antigen Detection |
| ELV693Rb01 | ELISA Kit for Arginase (ARG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV693Mo01 | Recombinant Arginase (ARG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV693Mo01 | Monoclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IP. |
| PAV693Mo01 | Polyclonal Antibody to Arginase (ARG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV693Mo01 | CLIA Kit for Arginase (ARG) | CLIA assay for Antigen Detection |
| ELV693Mo01 | ELISA Kit for Arginase (ARG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and nucleotide sequence of cDNA for human liver arginase."
Proc. Natl. Acad. Sci. U.S.A. 84:412-415(1987) [PubMed] [Europe PMC] [Abstract]
"Human liver-type arginase gene: structure of the gene and analysis of the promoter region."
Nucleic Acids Res. 16:8789-8802(1988) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Expression of human liver arginase in Escherichia coli. Purification and properties of the product."
Biochem. J. 270:697-703(1990) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response."
Proc. Natl. Acad. Sci. U.S.A. 102:13058-13063(2005) [PubMed] [Europe PMC] [Abstract]
"Expression, purification, assay, and crystal structure of perdeuterated human arginase I."
Arch. Biochem. Biophys. 465:82-89(2007) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster."
J. Am. Chem. Soc. 129:6388-6389(2007) [PubMed] [Europe PMC] [Abstract]
"Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I."
Org. Biomol. Chem. 6:3240-3243(2008) [PubMed] [Europe PMC] [Abstract]
"Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia."
Am. J. Hum. Genet. 51:1406-1412(1992) [PubMed] [Europe PMC] [Abstract]
"Molecular genetic study of human arginase deficiency."
Am. J. Hum. Genet. 50:1281-1290(1992) [PubMed] [Europe PMC] [Abstract]
"Molecular basis of phenotypic variation in patients with argininemia."
Hum. Genet. 96:255-260(1995) [PubMed] [Europe PMC] [Abstract]
"Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes."
Gene 509:124-130(2012) [PubMed] [Europe PMC] [Abstract]
"Five novel mutations in ARG1 gene in Chinese patients of argininemia."
Pediatr. Neurol. 49:119-123(2013) [PubMed] [Europe PMC] [Abstract]