Macrophage Stimulating Protein (MSP)
MST1; HGFL; NF15S2; Hepatocyte Growth Factor-Like Protein; Macrophage Stimulating 1
MST1 cDNA from a human liver cDNA library. The deduced protein contains 4 kringle domains followed by a serine protease domain. Because this domain structure was identical to that found in hepatic growth factor (HGF), Han et al. proposed that the protein be called HGFL. The 2 proteins share about 50% sequence identity.To assess the in vivo effects of total loss of HGFL, Bezerra et al. generated mice with targeted disruption of the gene resulting in loss of the protein. Embryogenesis proceeded normally and followed a mendelian pattern of genetic transmission. Mice homozygous for the targeted allele, Hgfl -/- mice, were fertile and grew to adulthood without obvious phenotypic abnormalities in unchallenged animals, except for development of lipid-containing cytoplasmic vacuoles in hepatocytes throughout the liver lobules.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV692Hu01 | Recombinant Macrophage Stimulating Protein (MSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV692Hu01 | Monoclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IP. |
| PAV692Hu01 | Polyclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV692Hu01 | CLIA Kit for Macrophage Stimulating Protein (MSP) | CLIA assay for Antigen Detection |
| ELV692Hu01 | ELISA Kit for Macrophage Stimulating Protein (MSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV692Mu01 | Recombinant Macrophage Stimulating Protein (MSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV692Mu01 | Monoclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IP. |
| PAV692Mu01 | Polyclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV692Mu01 | CLIA Kit for Macrophage Stimulating Protein (MSP) | CLIA assay for Antigen Detection |
| ELV692Mu01 | ELISA Kit for Macrophage Stimulating Protein (MSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV692Ra01 | Recombinant Macrophage Stimulating Protein (MSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV692Ra01 | Monoclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IP. |
| PAV692Ra01 | Polyclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV692Ra01 | CLIA Kit for Macrophage Stimulating Protein (MSP) | CLIA assay for Antigen Detection |
| ELV692Ra01 | ELISA Kit for Macrophage Stimulating Protein (MSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV692Ca01 | Recombinant Macrophage Stimulating Protein (MSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV692Ca01 | Monoclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IP. |
| PAV692Ca01 | Polyclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV692Ca01 | CLIA Kit for Macrophage Stimulating Protein (MSP) | CLIA assay for Antigen Detection |
| ELV692Ca01 | ELISA Kit for Macrophage Stimulating Protein (MSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV692Po01 | Recombinant Macrophage Stimulating Protein (MSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV692Po01 | Monoclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IP. |
| PAV692Po01 | Polyclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV692Po01 | CLIA Kit for Macrophage Stimulating Protein (MSP) | CLIA assay for Antigen Detection |
| ELV692Po01 | ELISA Kit for Macrophage Stimulating Protein (MSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV692Bo01 | Recombinant Macrophage Stimulating Protein (MSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV692Bo01 | Monoclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IP. |
| PAV692Bo01 | Polyclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV692Bo01 | CLIA Kit for Macrophage Stimulating Protein (MSP) | CLIA assay for Antigen Detection |
| ELV692Bo01 | ELISA Kit for Macrophage Stimulating Protein (MSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV692Rb01 | Recombinant Macrophage Stimulating Protein (MSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV692Rb01 | Monoclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IP. |
| PAV692Rb01 | Polyclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV692Rb01 | CLIA Kit for Macrophage Stimulating Protein (MSP) | CLIA assay for Antigen Detection |
| ELV692Rb01 | ELISA Kit for Macrophage Stimulating Protein (MSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV692Mo01 | Recombinant Macrophage Stimulating Protein (MSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV692Mo01 | Monoclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IP. |
| PAV692Mo01 | Polyclonal Antibody to Macrophage Stimulating Protein (MSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV692Mo01 | CLIA Kit for Macrophage Stimulating Protein (MSP) | CLIA assay for Antigen Detection |
| ELV692Mo01 | ELISA Kit for Macrophage Stimulating Protein (MSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor."
Biochemistry 30:9768-9780(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3."
J. Biol. Chem. 268:15461-15468(1993) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity."
J. Exp. Med. 173:1227-1234(1991) [PubMed] [Europe PMC] [Abstract]
"Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain."
J. Biol. Chem. 272:16999-17004(1997) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis."
Mucosal Immunol. 1:131-138(2008) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Genome-wide association identifies multiple ulcerative colitis susceptibility loci."
Nat. Genet. 42:332-337(2010) [PubMed] [Europe PMC] [Abstract]
"Proteolytic activation of pro-macrophage-stimulating protein by hepsin."
Mol. Cancer Res. 9:1175-1186(2011) [PubMed] [Europe PMC] [Abstract]
"Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution."
PLoS ONE 6:E27269-E27269(2011) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein."
FEBS J. 272:5799-5807(2005) [PubMed] [Europe PMC] [Abstract]