Call Now

Deoxyribonuclease I (DNASE1)

DNaseI; DNL1; DRNI; DNase-I; Dornase alfa

DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. It has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis.DNase I binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. The function of this interaction is unclear. However since actin-bound DNase I is enzymatically inactive, the DNase-actin complex might be a storage form of DNase I that prevents damage of the genetic information.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V686Hu01 Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies MV686Hu21 Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
PV686Hu01 Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
LV686Hu71 Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
LV686Hu82 FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits KEV686Hu ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V686Mu01 Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
PV686Mu01 Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits KEV686Mu ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V686Bo01 Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies MV686Bo21 Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
PV686Bo01 Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits KEV686Bo ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyribonuclease I (DNASE1) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyribonuclease I (DNASE1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyribonuclease I (DNASE1) CLIA assay for Antigen Detection

Reference

"Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum."
Proc. Natl. Acad. Sci. U.S.A. 87:9188-9192(1990) [PubMed] [Europe PMC] [Abstract]

"Structure of the human deoxyribonuclease I (DNase I) gene: identification of the nucleotide substitution that generates its classical genetic polymorphism."
Ann. Hum. Genet. 59:1-15(1995) [PubMed] [Europe PMC] [Abstract]

"DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis."
Eur. J. Immunol. 31:743-751(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation."
FEBS J. 273:3094-3105(2006) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A human urine-derived interleukin 1 inhibitor. Homology with deoxyribonuclease I."
J. Exp. Med. 168:1767-1779(1988) [PubMed] [Europe PMC] [Abstract]

"Human genetically polymorphic deoxyribonuclease: purification, characterization, and multiplicity of urine deoxyribonuclease I."
J. Biochem. 108:393-398(1990) [PubMed] [Europe PMC] [Abstract]

"Mutation of DNASE1 in people with systemic lupus erythematosus."
Nat. Genet. 28:313-314(2001) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of the third allele of human deoxyribonuclease I polymorphism."
Ann. Hum. Genet. 59:139-147(1995) [PubMed] [Europe PMC] [Abstract]

"The molecular basis for genetic polymorphism of human deoxyribonuclease I: identification of the nucleotide substitution that generates the fourth allele."
FEBS Lett. 359:211-214(1995) [PubMed] [Europe PMC] [Abstract]

"The fifth allele of the human deoxyribonuclease I (DNase I) polymorphism."
Electrophoresis 18:1936-1939(1997) [PubMed] [Europe PMC] [Abstract]

"A new allele, DNASE1*6, of human deoxyribonuclease I polymorphism encodes an Arg to Cys substitution responsible for its instability."
Biochem. Biophys. Res. Commun. 260:280-283(1999) [PubMed] [Europe PMC] [Abstract]