Sialic Acid Binding Ig Like Lectin 2 (SIGLEC2)

CD22; BL-CAM; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; T-cell surface antigen Leu-14

SPN	V675
HGNC	1643
MGI	88322
PubMed	17562860
RGD	1311610
UniProt	P20273
Wiki	CD22

CD22 is expressed early in B-cell development in pro-B cells, as a cytoplasmic protein, and later in B-cell development, at the late pre-B-cell stage, as a cell surface protein. Once expressed as a membrane protein, CD22 persists on B cells until they differentiate into plasma cells. The presence of cytoplasmic CD22 is a useful marker for B-cell precursor acute lymphocytic leukemia. CD22 appears to be a heterodimer consisting of 130- and 140-kD glycoproteins with protein cores of 80 and 100 kD, respectively. The 2 subunits are thought to be independently transported to the surface and originate from 2 separate precursor molecules. The CD22 polypeptide is structurally related to myelin-associated glycoprotein (MAG), neural cell adhesion molecule (NCAM), and carcinoembryonic antigen (CEA).

Reference

"The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion."
Nature 345:74-77(1990) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions."
J. Exp. Med. 173:137-146(1991) [PubMed] [Europe PMC] [Abstract]

"Genomic structure and chromosomal mapping of the human CD22 gene."
J. Immunol. 150:5013-5024(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of the gene variations in human CD22."
Immunogenetics 49:280-286(1999) [PubMed] [Europe PMC] [Abstract]

"Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition."
J. Biol. Chem. 268:7019-7027(1993) [PubMed] [Europe PMC] [Abstract]

"A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP."
Science 269:242-244(1995) [PubMed] [Europe PMC] [Abstract]

"Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22."
Eur. J. Immunol. 26:1246-1252(1996) [PubMed] [Europe PMC] [Abstract]

"CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation."
J. Exp. Med. 183:547-560(1996) [PubMed] [Europe PMC] [Abstract]

"CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling."
Annu. Rev. Immunol. 15:481-504(1997) [PubMed] [Europe PMC] [Abstract]