Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5)

CD84; LY9B; Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84

SPN	V667
HGNC	1704
MGI	1336885
PubMed	23064403
RGD	1564553
UniProt	Q9UIB8
Wiki	CD84

CD84 encodes a 328-amino acid protein that is shortened to 307 amino acids after cleavage of the signal peptide. The protein has 4 potential N-linked and 29 potential O-linked glycosylation sites. The observed molecular mass on SDS-PAGE is 64 to 82 kD, which endoglycosidase treatment reduces to 46 kD and 36 kD products, close to the calculated mass of approximately 35 kD. In addition to a 25-amino acid transmembrane region and an 83-amino acid cytoplasmic region, CD84 has a 189-amino acid extracellular segment composed of 2 Ig-like domains similar to that found in other members of the CD2 family. Northern blot analysis revealed mRNA expression of a 4.4-kb transcript at high levels in lymphoid tissue and at lower levels in lung; no expression was found in liver.

Reference

"CD84 leukocyte antigen is a new member of the Ig superfamily."
Blood 90:2398-2405(1997) [PubMed] [Europe PMC] [Abstract]

"Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84."
Biochem. J. 346:729-736(2000) [PubMed] [Europe PMC] [Abstract]

"Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains."
Tissue Antigens 55:118-127(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP."
Blood 97:3867-3874(2001) [PubMed] [Europe PMC] [Abstract]

"Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family."
Clin. Immunol. 100:15-23(2001) [PubMed] [Europe PMC] [Abstract]

"CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A."
J. Immunol. 166:5480-5487(2001) [PubMed] [Europe PMC] [Abstract]

"CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1."
J. Immunol. 167:3668-3676(2001) [PubMed] [Europe PMC] [Abstract]

"CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2."
Eur. J. Immunol. 32:1640-1649(2002) [PubMed] [Europe PMC] [Abstract]

"Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation."
J. Immunol. 171:2485-2495(2003) [PubMed] [Europe PMC] [Abstract]

"CD84 expression on human hematopoietic progenitor cells."
Exp. Hematol. 31:798-805(2003) [PubMed] [Europe PMC] [Abstract]

"Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)."
Tissue Antigens 64:132-144(2004) [PubMed] [Europe PMC] [Abstract]

"Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling."
Blood 106:3028-3034(2005) [PubMed] [Europe PMC] [Abstract]

"Structure of CD84 provides insight into SLAM family function."
Proc. Natl. Acad. Sci. U.S.A. 104:10583-10588(2007) [PubMed] [Europe PMC] [Abstract]