Mitogen Activated Protein Kinase 8 (MAPK8)

JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; JUN N-Terminal Kinase; Stress-activated protein kinase 1c; c-Jun N-terminal kinase 1

SPN	V666
HGNC	6881
MGI	1346861
PubMed	18222916
RGD	621506
UniProt	P45983
Wiki	MAPK8

Mitogen-activated protein kinase 8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.

This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway.

Reference

"JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain."
Cell 76:1025-1037(1994) [PubMed] [Europe PMC] [Abstract]

"Selective interaction of JNK protein kinase isoforms with transcription factors."
EMBO J. 15:2760-2770(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms."
Science 267:682-685(1995) [PubMed] [Europe PMC] [Abstract]

"Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7."
Biochem. J. 352:145-154(2000) [PubMed] [Europe PMC] [Abstract]

"The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death."
EMBO J. 19:2958-2968(2000) [PubMed] [Europe PMC] [Abstract]

"JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis."
J. Biol. Chem. 278:9195-9202(2003) [PubMed] [Europe PMC] [Abstract]

"Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein."
Biochem. J. 389:73-82(2005) [PubMed] [Europe PMC] [Abstract]

"Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26."
Mol. Cell. Biol. 26:3282-3294(2006) [PubMed] [Europe PMC] [Abstract]

"Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation."
Cancer Res. 67:8725-8735(2007) [PubMed] [Europe PMC] [Abstract]

"Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing."
J. Biol. Chem. 282:6484-6493(2007) [PubMed] [Europe PMC] [Abstract]

"Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1."
Mol. Cell. Biol. 27:2861-2869(2007) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."
Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract]

"JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy."
Mol. Cell 30:678-688(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of SCCA1 and insight about the interaction with JNK1."
Biochem. Biophys. Res. Commun. 380:143-147(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"JNK1 phosphorylates SIRT1 and promotes its enzymatic activity."
PLoS ONE 4:E8414-E8414(2009) [PubMed] [Europe PMC] [Abstract]

"JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis."
Cell Death Dis. 1:E29-E29(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"A critical step for JNK activation: isomerization by the prolyl isomerase Pin1."
Cell Death Differ. 19:153-161(2012) [PubMed] [Europe PMC] [Abstract]

"JNK regulates the photic response of the mammalian circadian clock."
EMBO Rep. 13:455-461(2012) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells."
Int. J. Biochem. Cell Biol. 43:409-415(2011) [PubMed] [Europe PMC] [Abstract]

"Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis."
Mol. Biol. Cell 22:117-127(2011) [PubMed] [Europe PMC] [Abstract]

"JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress."
Mol. Cell 44:62-71(2011) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125."
EMBO J. 23:2185-2195(2004) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]