Thioredoxin Binding Protein 2 (TBP2)

TXNIP; HHCPA78; THIF; VDUP1; Thioredoxin Interacting Protein; Vitamin D3-Upregulated Protein 1; Upregulated By 1,25-Dihydroxyvitamin D-3

SPN	V660
HGNC	16952
MGI	1889549
PubMed	19759265
RGD	620886
UniProt	Q9H3M7
Wiki	TXNIP

Exposure to vitamin D3 (1,25-dihydroxyvitamin D3) or phorbol ester induces the bipotent HL-60 cell promyelocytic leukemia cell line to differentiate into monocytes/macrophages, whereas retinoic acid and dimethylsulfoxide induce differentiation towards granulocytes. The differentiation is accompanied by regulation of MYC , FOS , FMS (CSF1R), and myeloblastin (PRTN3;). By differential screening of HL60 cell lines, Chen and DeLuca (1994) identified a cDNA encoding TXNIP, which they termed VDUP1. The deduced TXNIP protein has 391 amino acids. Ribonuclease protection analysis showed dramatically increased expression of TXNIP in response to vitamin D3 but not to phorbol ester. Chen and DeLuca (1994) concluded that TXNIP is not involved in the differentiation process.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV660Hu01	Recombinant Thioredoxin Binding Protein 2 (TBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV660Hu01	Monoclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IP.
Antibodies	PAV660Hu01	Polyclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IF.
Assay Kits	CLV660Hu01	CLIA Kit for Thioredoxin Binding Protein 2 (TBP2)	CLIA assay for Antigen Detection
Assay Kits	ELV660Hu01	ELISA Kit for Thioredoxin Binding Protein 2 (TBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV660Mu01	Recombinant Thioredoxin Binding Protein 2 (TBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV660Mu01	Monoclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IP.
Antibodies	PAV660Mu01	Polyclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IF.
Assay Kits	CLV660Mu01	CLIA Kit for Thioredoxin Binding Protein 2 (TBP2)	CLIA assay for Antigen Detection
Assay Kits	ELV660Mu01	ELISA Kit for Thioredoxin Binding Protein 2 (TBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV660Ra01	Recombinant Thioredoxin Binding Protein 2 (TBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV660Ra01	Monoclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IP.
Antibodies	PAV660Ra01	Polyclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IF.
Assay Kits	CLV660Ra01	CLIA Kit for Thioredoxin Binding Protein 2 (TBP2)	CLIA assay for Antigen Detection
Assay Kits	ELV660Ra01	ELISA Kit for Thioredoxin Binding Protein 2 (TBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV660Ca01	Recombinant Thioredoxin Binding Protein 2 (TBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV660Ca01	Monoclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IP.
Antibodies	PAV660Ca01	Polyclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IF.
Assay Kits	CLV660Ca01	CLIA Kit for Thioredoxin Binding Protein 2 (TBP2)	CLIA assay for Antigen Detection
Assay Kits	ELV660Ca01	ELISA Kit for Thioredoxin Binding Protein 2 (TBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV660Po01	Recombinant Thioredoxin Binding Protein 2 (TBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV660Po01	Monoclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IP.
Antibodies	PAV660Po01	Polyclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IF.
Assay Kits	CLV660Po01	CLIA Kit for Thioredoxin Binding Protein 2 (TBP2)	CLIA assay for Antigen Detection
Assay Kits	ELV660Po01	ELISA Kit for Thioredoxin Binding Protein 2 (TBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV660Bo01	Recombinant Thioredoxin Binding Protein 2 (TBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV660Bo01	Monoclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IP.
Antibodies	PAV660Bo01	Polyclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IF.
Assay Kits	CLV660Bo01	CLIA Kit for Thioredoxin Binding Protein 2 (TBP2)	CLIA assay for Antigen Detection
Assay Kits	ELV660Bo01	ELISA Kit for Thioredoxin Binding Protein 2 (TBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV660Rb01	Recombinant Thioredoxin Binding Protein 2 (TBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV660Rb01	Monoclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IP.
Antibodies	PAV660Rb01	Polyclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IF.
Assay Kits	CLV660Rb01	CLIA Kit for Thioredoxin Binding Protein 2 (TBP2)	CLIA assay for Antigen Detection
Assay Kits	ELV660Rb01	ELISA Kit for Thioredoxin Binding Protein 2 (TBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV660Mo01	Recombinant Thioredoxin Binding Protein 2 (TBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV660Mo01	Monoclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IP.
Antibodies	PAV660Mo01	Polyclonal Antibody to Thioredoxin Binding Protein 2 (TBP2)	WB; IHC; ICC; IF.
Assay Kits	CLV660Mo01	CLIA Kit for Thioredoxin Binding Protein 2 (TBP2)	CLIA assay for Antigen Detection
Assay Kits	ELV660Mo01	ELISA Kit for Thioredoxin Binding Protein 2 (TBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3."
Biochim. Biophys. Acta 1219:26-32(1994) [PubMed] [Europe PMC] [Abstract]

"Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2)."
Exp. Eye Res. 85:270-279(2007) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression."
Oncogene 22:4035-4046(2003) [PubMed] [Europe PMC] [Abstract]

"hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip."
Biochem. Biophys. Res. Commun. 372:880-885(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation."
J. Biol. Chem. 285:8869-8879(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1."
Oncogene 30:3792-3801(2011) [PubMed] [Europe PMC] [Abstract]

"Structure of the N-terminal domain of human thioredoxin-interacting protein."
Acta Crystallogr. D 69:333-344(2013) [PubMed] [Europe PMC] [Abstract]