Nucleoporin 214kDa (NUP214)

CAIN; CAN; N214; Nuclear Pore Complex Protein Nup214; CAN Protein,Putative Oncogene

SPN	V653
HGNC	8064
MGI	1095411
PubMed	16943420
RGD	1304977
UniProt	P35658
Wiki	NUP214

Nucleoporin 214kDa(NUP214;CAN),The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins.

The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome.

Reference

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