Lysozyme (LZM)

LYZ; Renal Amyloidosis; N-Acetylmuramide Glycanhydrolase; Muramidase; 1,4-beta-N-acetylmuramidase C

SPN	V631
HGNC	6740
MGI	96897
PubMed	20413917
RGD	3026
UniProt	P61626
Wiki	Lysozyme

Lysozyme, also known as muramidase or N-acetylmuramide glycanhydrolase, are a family of enzymes (EC 3.2.1.17) which damage bacterial cell walls by catalyzing hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Lysozyme is abundant in a number of secretions, such as tears, saliva, human milk and mucus. It is also present in cytoplasmic granules of the polymorphonuclear neutrophils (PMN). Large amounts of lysozyme can be found in egg white. C-type lysozymes are closely related to alpha-lactalbumin in sequence and structure making them part of the same family.

Reference

"Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae."
Gene 66:223-234(1988) [PubMed] [Europe PMC] [Abstract]

"Cloning the human lysozyme cDNA: inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells."
Proc. Natl. Acad. Sci. U.S.A. 85:6227-6231(1988) [PubMed] [Europe PMC] [Abstract]

"Human lysozyme: sequencing of a cDNA, and expression and secretion by Saccharomyces cerevisiae."
Biochem. Biophys. Res. Commun. 150:794-801(1988) [PubMed] [Europe PMC] [Abstract]

"The human lysozyme gene. Sequence organization and chromosomal localization."
Eur. J. Biochem. 182:507-516(1989) [PubMed] [Europe PMC] [Abstract]

"The cloning, sequencing and analysis of Chinese human lysozyme gene cDNA amplified with RT-PCR from human placental total RNA."
Sheng Wu Hua Hsueh Tsa Chih 9:269-273(1993)

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Primary structure of lysozymes from man and goose."
Nature New Biol. 232:16-17(1971) [PubMed] [Europe PMC] [Abstract]

"A Val-Val sequence found in a human monocytic leukemia lysozyme."
FEBS Lett. 22:34-36(1972) [PubMed] [Europe PMC] [Abstract]

"Human milk lysozyme: unpublished data concerning the establishment of the complete primary structure; comparison with lysozymes of various origins."
Helv. Chim. Acta 54:2668-2675(1971) [PubMed] [Europe PMC] [Abstract]

"Comparison between human and bird lysozymes: note concerning the previously observed deletion."
FEBS Lett. 22:31-33(1972) [PubMed] [Europe PMC] [Abstract]

"Indication of possible post-translational formation of disulphide bonds in the beta-sheet domain of human lysozyme."
Biochem. J. 292:469-476(1993) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The high resolution X-ray study of human. lysozyme: a preliminary analysis."
(In) Osserman E.F., Canfield R.E., Beychok S. (eds.);Lysozyme, pp.71-79, Academic Press, New York (1974)

"Refinement of human lysozyme at 1.5-A resolution analysis of non-bonded and hydrogen-bond interactions."
J. Mol. Biol. 152:737-762(1981) [PubMed] [Europe PMC] [Abstract]

"X-ray studies of water in crystals of lysozyme."
J. Mol. Biol. 167:693-723(1983) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of a mutant human lysozyme C77/95A with increased secretion efficiency in yeast."
J. Biol. Chem. 266:12599-12603(1991) [PubMed] [Europe PMC] [Abstract]

"Structures of monoclinic lysozyme iodide at 1.6 A and of triclinic lysozyme nitrate at 1.1 A."
Acta Crystallogr. D 54:767-780(1998) [PubMed] [Europe PMC] [Abstract]

"1H NMR studies of human lysozyme: spectral assignment and comparison with hen lysozyme."
Biochemistry 29:7201-7214(1990) [PubMed] [Europe PMC] [Abstract]

"1H and 15N NMR study of human lysozyme."
J. Biochem. 110:1022-1029(1991) [PubMed] [Europe PMC] [Abstract]

"Human lysozyme gene mutations cause hereditary systemic amyloidosis."
Nature 362:553-557(1993) [PubMed] [Europe PMC] [Abstract]