Glia Maturation Factor Gamma (GMFg)

SPN	V629
HGNC	4374
MGI	1927135
PubMed	17127212
RGD	620506
UniProt	O60234
Wiki	GMF

• GMF-gamma was expressed as a 0.9-kb mRNA predominantly in lung, heart, and placenta. An additional low-abundance 1.2-kb transcript was detected in heart and skeletal muscle. Independently, Mao et al. (1998) identified a cDNA corresponding to GMF-gamma, which they referred to as a GMF-beta homolog, among a collection of cDNAs expressed in hematopoietic stem/progenitor cells.

• GMF-gamma gene had been mapped to 19q13.2. This region is frequently deleted in human malignant gliomas and was thus suspected to harbor a glioma tumor suppressor gene. Given the putative role of GMF-gamma in cell differentiation and proliferation, and its map location, it became a candidate for said tumor suppressor gene.

Reference

"Isolation of novel human cDNA (hGMF-gamma) homologous to glia maturation factor-beta gene."
Biochim. Biophys. Acta 1396:242-244(1998) [PubMed] [Europe PMC] [Abstract]

"The human glia maturation factor-gamma gene: genomic structure and mutation analysis in gliomas with chromosome 19q loss."
Neurogenetics 2:163-166(1999) [PubMed] [Europe PMC] [Abstract]

"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human glia maturation factor, gamma (GMFG)."
Submitted (FEB-2010) to the PDB data bank