Sperm Specific Antigen 2 (SSFA2)

CS-1; CS1; KRAP; SPAG13; Cleavage signal-1 protein; Ki-ras-induced actin-interacting protein

SPN	V624
HGNC	11319
MGI	1917849
PubMed	12586324
RGD	1310767
UniProt	P28290
Wiki	SSFA2

Sperm surface molecules have been shown to be transferred to the egg membrane during fertilization. Thus, the sperm cell can share in or impart antigenic specificities to fertilized ova and cleaving embryos. The molecules that are incorporated into the oocyte may provide an extranuclear signal to the oocyte to cleave. The sperm surface antigen involved in some step of early cleavage of the fertilized oocyte is a doublet of proteins of approximately 14 kD and 18 kD. Antibodies to this protein inhibit early cleavage of the oocyte without affecting pronuclear formation.No homology was found to any known sequence, indicating that CS1 is a unique protein. In a rabbit reticulocyte in vitro translation system, the transcribed CS1 RNA produced a 33-kD CS1 protein. The 2 parts of the antigen are presumably derived from 1 transcript.

Reference

"Deregulated expression of KRAP, a novel gene encoding actin-interacting protein, in human colon cancer cells."
J. Hum. Genet. 49:46-52(2004) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human cleavage signal-1 protein; cDNA cloning, transcription and immunological analysis."
Gene 112:205-211(1992) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]