Contactin 1 (CNTN1)

F3; Glycoprotein gP135; Neural cell surface protein F3

SPN	V623
HGNC	2171
MGI	105980
PubMed	16510572
RGD	621300
UniProt	Q12860
Wiki	CNTN1

Contactin 1, also known as CNTN1, is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Chick contactin (also known as F11 in the chick and F3 in the mouse) is a neuronal cell adhesion molecule of the immunoglobulin superfamily that is composed of 6 C2 Ig domains and 4 fibronectin type III (FN-III) repeats. In the developing mouse cerebellum, contactin is confined to discrete neuronal subpopulations and subcompartments, for example, the granule cell axons, Golgi cells, and mossy fibers, while in contrast, stellate cells and Purkinje cell bodies and dendrites are devoid of contactin expression.

Reference

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"The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]

"Solution structures of the FN3 domain of human contactin 1."
Submitted (AUG-2007) to the PDB data bank

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Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy."
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