C-Type Lectin Domain Family 2, Member C (CLEC2C)

CD69; CLEC2-C; AIM; p60; EA1; MLR-3; Early T-Cell Activation Antigen p60; Early activation antigen CD69; Activation inducer molecule; Leukocyte surface antigen Leu-23

SPN	V617
HGNC	1694
MGI	88343
PubMed	12039905
RGD	61318
UniProt	Q07108
Wiki	CD69

The activation of T lymphocytes, both in vivo and in vitro, induces expression of CD69. This molecule, which appears to be the earliest inducible cell surface glycoprotein acquired during lymphoid activation, is involved in lymphocyte proliferation and functions as a signal-transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets (Cambiaggi et al., 1992)The CD69 clone hybridized to a 1.7-kb mRNA species that was rapidly induced and degraded after lymphocyte stimulation, consistent with the presence of rapid degradation signals at the 3-prime untranslated region. Protein sequence homology search demonstrated that CD69 is a member of the same superfamily of type II transmembrane receptors as natural killer cell lectin (NKG2), which also maps to chromosome 12.

Reference

"Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain."
J. Immunol. 150:4920-4927(1993) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors."
J. Exp. Med. 178:537-547(1993) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens."
Eur. J. Immunol. 23:1643-1648(1993) [PubMed] [Europe PMC] [Abstract]

"Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors."
Eur. J. Immunol. 24:1692-1697(1994) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells."
Biochemistry 39:14779-14786(2000) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69."
J. Biol. Chem. 276:7312-7319(2001) [PubMed] [Europe PMC] [Abstract]

"Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice."
FEBS J. 275:5589-5606(2008) [PubMed] [Europe PMC] [Abstract]