Retinoblastoma Protein 1 (RB1)

OSRC; PRB; p105-Rb; pp110; Including Osteosarcoma; Retinoblastoma-associated protein

SPN	V613
HGNC	9884
MGI	97874
PubMed	8384581
RGD	3540
UniProt	P06400
Wiki	RB1

The retinoblastoma protein (abbreviated pRb or Rb) is a tumor suppressor protein that is dysfunctional in many types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer.

In humans, the protein is encoded by the RB1 gene located on 13q14.1-q14.2. If both alleles of this gene are mutated early in life, the protein is inactivated and results in development of retinoblastoma cancer, hence the name Rb.

Reference

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