Alkaline Phosphatase, Placental (ALPP)
PLAP1; ALP; ALPG; ALPPL; GCAP; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).
Alkaline phosphatase, placental is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV605Hu01 | Recombinant Alkaline Phosphatase, Placental (ALPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV605Hu01 | Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IP. |
| PAV605Hu01 | Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV605Hu01 | CLIA Kit for Alkaline Phosphatase, Placental (ALPP) | CLIA assay for Antigen Detection |
| ELV605Hu01 | ELISA Kit for Alkaline Phosphatase, Placental (ALPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV605Mu01 | Recombinant Alkaline Phosphatase, Placental (ALPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV605Mu01 | Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IP. |
| PAV605Mu01 | Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV605Mu01 | CLIA Kit for Alkaline Phosphatase, Placental (ALPP) | CLIA assay for Antigen Detection |
| ELV605Mu01 | ELISA Kit for Alkaline Phosphatase, Placental (ALPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV605Ra01 | Recombinant Alkaline Phosphatase, Placental (ALPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV605Ra01 | Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IP. |
| PAV605Ra01 | Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV605Ra01 | CLIA Kit for Alkaline Phosphatase, Placental (ALPP) | CLIA assay for Antigen Detection |
| ELV605Ra01 | ELISA Kit for Alkaline Phosphatase, Placental (ALPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV605Ca01 | Recombinant Alkaline Phosphatase, Placental (ALPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV605Ca01 | Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IP. |
| PAV605Ca01 | Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV605Ca01 | CLIA Kit for Alkaline Phosphatase, Placental (ALPP) | CLIA assay for Antigen Detection |
| ELV605Ca01 | ELISA Kit for Alkaline Phosphatase, Placental (ALPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV605Po01 | Recombinant Alkaline Phosphatase, Placental (ALPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV605Po01 | Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IP. |
| PAV605Po01 | Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV605Po01 | CLIA Kit for Alkaline Phosphatase, Placental (ALPP) | CLIA assay for Antigen Detection |
| ELV605Po01 | ELISA Kit for Alkaline Phosphatase, Placental (ALPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV605Bo01 | Recombinant Alkaline Phosphatase, Placental (ALPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV605Bo01 | Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IP. |
| PAV605Bo01 | Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV605Bo01 | CLIA Kit for Alkaline Phosphatase, Placental (ALPP) | CLIA assay for Antigen Detection |
| ELV605Bo01 | ELISA Kit for Alkaline Phosphatase, Placental (ALPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV605Rb01 | Recombinant Alkaline Phosphatase, Placental (ALPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV605Rb01 | Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IP. |
| PAV605Rb01 | Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV605Rb01 | CLIA Kit for Alkaline Phosphatase, Placental (ALPP) | CLIA assay for Antigen Detection |
| ELV605Rb01 | ELISA Kit for Alkaline Phosphatase, Placental (ALPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV605Mo01 | Recombinant Alkaline Phosphatase, Placental (ALPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV605Mo01 | Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IP. |
| PAV605Mo01 | Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV605Mo01 | CLIA Kit for Alkaline Phosphatase, Placental (ALPP) | CLIA assay for Antigen Detection |
| ELV605Mo01 | ELISA Kit for Alkaline Phosphatase, Placental (ALPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution."
J. Biol. Chem. 263:12020-12027(1988) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and sequence analysis of human placental alkaline phosphatase."
J. Biol. Chem. 261:3112-3115(1986) [PubMed] [Europe PMC] [Abstract]
"Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids."
Proc. Natl. Acad. Sci. U.S.A. 83:5597-5601(1986) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA."
Proc. Natl. Acad. Sci. U.S.A. 82:8715-8719(1985) [PubMed] [Europe PMC] [Abstract]
"Purification and partial sequencing of human placental alkaline phosphatase."
Biochem. Biophys. Res. Commun. 116:1076-1083(1983) [PubMed] [Europe PMC] [Abstract]
"Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells."
Proc. Natl. Acad. Sci. U.S.A. 83:3781-3785(1986) [PubMed] [Europe PMC] [Abstract]
"Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme."
Proc. Natl. Acad. Sci. U.S.A. 85:1398-1402(1988) [PubMed] [Europe PMC] [Abstract]
"Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase."
Proc. Natl. Acad. Sci. U.S.A. 87:157-161(1990) [PubMed] [Europe PMC] [Abstract]
"Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein."
J. Cell Biol. 116:799-807(1992) [PubMed] [Europe PMC] [Abstract]
"Function assignment to conserved residues in mammalian alkaline phosphatases."
J. Biol. Chem. 277:22992-22999(2002) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity."
J. Biol. Chem. 276:9158-9165(2001) [PubMed] [Europe PMC] [Abstract]
"Structural studies of human placental alkaline phosphatase in complex with functional ligands."
J. Mol. Biol. 350:441-451(2005) [PubMed] [Europe PMC] [Abstract]
"Structural studies of human alkaline phosphatase in complex with strontium: implication for its secondary effect in bones."
Protein Sci. 15:1691-1700(2006) [PubMed] [Europe PMC] [Abstract]
"Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site."
Acta Crystallogr. F 66:866-870(2010) [PubMed] [Europe PMC] [Abstract]