Call Now

Cyclin Dependent Kinase 4 (CDK4)

CMM3; PSK-J3; Cell division protein kinase 4

Cyclin-dependent kinase 4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.It is regulated by Cyclin D.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV593Hu01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV593Hu01 Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
PAV593Hu01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IF.
Assay Kits CLV593Hu01 CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA assay for Antigen Detection
ELV593Hu01 ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV593Mu01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV593Mu01 Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
PAV593Mu01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IF.
Assay Kits CLV593Mu01 CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA assay for Antigen Detection
ELV593Mu01 ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV593Ra01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV593Ra01 Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
PAV593Ra01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IF.
Assay Kits CLV593Ra01 CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA assay for Antigen Detection
ELV593Ra01 ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV593Ca01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV593Ca01 Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
PAV593Ca01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IF.
Assay Kits CLV593Ca01 CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA assay for Antigen Detection
ELV593Ca01 ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV593Po01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV593Po01 Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
PAV593Po01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IF.
Assay Kits CLV593Po01 CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA assay for Antigen Detection
ELV593Po01 ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV593Bo01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV593Bo01 Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
PAV593Bo01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IF.
Assay Kits CLV593Bo01 CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA assay for Antigen Detection
ELV593Bo01 ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV593Rb01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV593Rb01 Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
PAV593Rb01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IF.
Assay Kits CLV593Rb01 CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA assay for Antigen Detection
ELV593Rb01 ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV593Mo01 Recombinant Cyclin Dependent Kinase 4 (CDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV593Mo01 Monoclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IP.
PAV593Mo01 Polyclonal Antibody to Cyclin Dependent Kinase 4 (CDK4) WB; IHC; ICC; IF.
Assay Kits CLV593Mo01 CLIA Kit for Cyclin Dependent Kinase 4 (CDK4) CLIA assay for Antigen Detection
ELV593Mo01 ELISA Kit for Cyclin Dependent Kinase 4 (CDK4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers."
Genomics 42:295-301(1997) [PubMed] [Europe PMC] [Abstract]

"A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma."
Science 269:1281-1284(1995) [PubMed] [Europe PMC] [Abstract]

"Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma."
Nat. Genet. 12:97-99(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family."
Proc. Natl. Acad. Sci. U.S.A. 84:388-392(1987) [PubMed] [Europe PMC] [Abstract]

"Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas."
Cancer Res. 53:5535-5541(1993) [PubMed] [Europe PMC] [Abstract]

"The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2."
EMBO J. 15:7060-7069(1996) [PubMed] [Europe PMC] [Abstract]

"New functional activities for the p21 family of CDK inhibitors."
Genes Dev. 11:847-862(1997) [PubMed] [Europe PMC] [Abstract]

"Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)."
Genes Dev. 13:3027-3033(1999) [PubMed] [Europe PMC] [Abstract]

"Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity."
Genes Dev. 18:912-925(2004) [PubMed] [Europe PMC] [Abstract]

"Cyclin-dependent kinases regulate the antiproliferative function of Smads."
Nature 430:226-231(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of VIK-1: a new Vav-interacting Kruppel-like protein."
Oncogene 24:28-38(2005) [PubMed] [Europe PMC] [Abstract]

"Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'."
Mol. Cell. Biol. 26:5070-5085(2006) [PubMed] [Europe PMC] [Abstract]

"Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition."
Cell Struct. Funct. 33:171-183(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest."
J. Biol. Chem. 284:5574-5581(2009) [PubMed] [Europe PMC] [Abstract]

"p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes."
Mol. Cell. Biol. 29:986-999(2009) [PubMed] [Europe PMC] [Abstract]

"Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation."
Mol. Cell. Biol. 29:4188-4200(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human CDK4 in complex with a D-type cyclin."
Proc. Natl. Acad. Sci. U.S.A. 106:4166-4170(2009) [PubMed] [Europe PMC] [Abstract]

"The structure of CDK4/cyclin D3 has implications for models of CDK activation."
Proc. Natl. Acad. Sci. U.S.A. 106:4171-4176(2009) [PubMed] [Europe PMC] [Abstract]

"Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma."
Int. J. Cancer 72:780-783(1997) [PubMed] [Europe PMC] [Abstract]

"Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France."
Hum. Mol. Genet. 7:209-216(1998) [PubMed] [Europe PMC] [Abstract]

Erratum
Hum. Mol. Genet. 7:941-941(1998)

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]