Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)

CD40; CDW40; Bp50; P50; B-cell surface antigen CD40; CD40L receptor

SPN	V578
HGNC	11919
MGI	88336
PubMed	20473910
RGD	619830
UniProt	P25942
Wiki	CD40

CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction.

Reference

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