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Glucagon (GC)

GCG; GLP1; GLP2; GRPP; Glicentin-Related Polypeptide; Glucagen; Oxyntomodulin; Incretin hormone

Glucagon has a major role in maintaining normal concentrations of glucose in blood, and is often described as having the opposite effect of insulin. That is, glucagon has the effect of increasing blood glucose levels. Glucagon is a linear peptide of 29 amino acids. Its primary sequence is almost perfectly conserved among vertebrates, and it is structurally related to the secretin family of peptide hormones.
Glucagon is synthesized as proglucagon and proteolytically processed to yield glucagon within alpha cells of the pancreatic islets. Proglucagon is also expressed within the intestinal tract, where it is processed not into glucagon, but to a family of glucagon-like peptides (enteroglucagon).

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V562Hu01 Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies MV562Hu22 Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
PV562Hu01 Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V562Mu01 Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
PV562Mu01 Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V562Ra01 Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies MV562Ra21 Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
PV562Ra01 Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V562Ga01 Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies MV562Ga21 Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
PV562Ga01 Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Glucagon (GC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Glucagon (GC) Bioactivity
Antibodies NONE Monoclonal Antibody to Glucagon (GC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Glucagon (GC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Glucagon (GC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Glucagon (GC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Glucagon (GC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Glucagon (GC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Glucagon (GC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Glucagon (GC) CLIA assay for Antigen Detection

Reference

"Glucagon gene expression in vertebrate brain."
J. Biol. Chem. 263:13475-13478(1988) [PubMed] [Europe PMC] [Abstract]

"Structure of the human glucagon gene."
Nucleic Acids Res. 14:4719-4730(1986) [PubMed] [Europe PMC] [Abstract]

"Exon duplication and divergence in the human preproglucagon gene."
Nature 304:368-371(1983) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The amino acid sequence of human glucagon."
FEBS Lett. 21:315-319(1972) [PubMed] [Europe PMC] [Abstract]

"Complete sequences of glucagon-like peptide-1 from human and pig small intestine."
J. Biol. Chem. 264:12826-12829(1989) [PubMed] [Europe PMC] [Abstract]

"Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable."
Diabetes 42:658-661(1993) [PubMed] [Europe PMC] [Abstract]

"Oxyntomodulin suppresses appetite and reduces food intake in humans."
J. Clin. Endocrinol. Metab. 88:4696-4701(2003) [PubMed] [Europe PMC] [Abstract]

"Postnatal and postprandial changes in plasma concentrations of glicentin in term and preterm infants."
Acta Paediatr. 92:1175-1179(2003) [PubMed] [Europe PMC] [Abstract]

"Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon."
FEBS Lett. 413:119-123(1997) [PubMed] [Europe PMC] [Abstract]

"Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment."
Protein Expr. Purif. 28:15-24(2003) [PubMed] [Europe PMC] [Abstract]

"Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2."
Can. J. Physiol. Pharmacol. 81:1005-1012(2003) [PubMed] [Europe PMC] [Abstract]

"Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis."
Mol. Endocrinol. 17:161-171(2003) [PubMed] [Europe PMC] [Abstract]

"Glucagon and regulation of glucose metabolism."
Am. J. Physiol. 284:E671-E678(2003) [PubMed] [Europe PMC] [Abstract]

"Glucagon-like peptide 2."
Trends Endocrinol. Metab. 10:153-156(1999) [PubMed] [Europe PMC] [Abstract]

"The glucagon-like peptides."
Endocr. Rev. 20:876-913(1999) [PubMed] [Europe PMC] [Abstract]

"Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity."
J. Med. Chem. 41:2693-2700(1998) [PubMed] [Europe PMC] [Abstract]

"NMR studies of the aggregation of glucagon-like peptide-1: formation of a symmetric helical dimer."
FEBS Lett. 515:165-170(2002) [PubMed] [Europe PMC] [Abstract]

"NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles."
Biochemistry 42:2825-2835(2003) [PubMed] [Europe PMC] [Abstract]