Kininogen 1 (KNG1)

BDK; KNG; HMWK; Alpha-2-Thiol Proteinase Inhibitor; Bradykinin; Kallidin; Fitzgerald factor; High molecular weight kininogen; Williams-Fitzgerald-Flaujeac factor; Ile-Ser-Bradykinin

SPN	V561
HGNC	6383
MGI	3027157
PubMed	23894665
RGD	2980
UniProt	P01042
Wiki	Kininogen_1

High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein -kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin from endothelial cells.

Reference

"Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen."
Biochemistry 23:5691-5697(1984) [PubMed] [Europe PMC] [Abstract]

"Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens."
J. Biol. Chem. 260:8601-8609(1985) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication."
Eur. J. Biochem. 154:471-478(1986) [PubMed] [Europe PMC] [Abstract]

"Human Ile-Ser-bradykinin, identical with rat T-kinin, is a major permeability factor in ovarian carcinoma ascites."
Biol. Chem. Hoppe-Seyler 367:1231-1234(1986) [PubMed] [Europe PMC] [Abstract]

"Ile-Ser-bradykinin is an aberrant permeability factor in various human malignant effusions."
Biol. Chem. Hoppe-Seyler 371:977-981(1990) [PubMed] [Europe PMC] [Abstract]

"The amino acid sequence of the light chain of human high-molecular-mass kininogen."
Eur. J. Biochem. 152:307-314(1985) [PubMed] [Europe PMC] [Abstract]

"Isolation and identification of hydroxyproline analogues of bradykinin in human urine."
FEBS Lett. 232:252-254(1988) [PubMed] [Europe PMC] [Abstract]

"Structural features of plasma kinins and kininogens."
Fed. Proc. 27:52-57(1968) [PubMed] [Europe PMC] [Abstract]

"Purification from human plasma of a tetrapeptide that potentiates insulin-like growth factor-I activity in chick embryo cartilage."
FEBS Lett. 373:207-211(1995) [PubMed] [Europe PMC] [Abstract]

"Disulfide bonds in bovine HMW kininogens."
Seikagaku 56:808-808(1984)

"Structural organization of the human kininogen gene and a model for its evolution."
J. Biol. Chem. 260:8610-8617(1985) [PubMed] [Europe PMC] [Abstract]

"Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer."
J. Biol. Chem. 263:16051-16054(1988) [PubMed] [Europe PMC] [Abstract]

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]