Membrane Cofactor Protein (MCP)

CD46; MIC10; TLX; TRA2; Trophoblast leukocyte common antigen; CD46 Molecule,Complement Regulatory Protein; CD46 Molecule,Complement Regulatory protein

SPN	V555
HGNC	6953
MGI	1203290
PubMed	1910685
RGD	3061
UniProt	P15529
Wiki	CD46

CD46 complement regulatory protein also known as CD46 ( is a protein which is encoded by the CD46 gene. CD46(MCP;MIC10) is an inhibitory complement receptor.This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. The protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization.

Reference

"Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins."
J. Exp. Med. 168:181-194(1988) [PubMed] [Europe PMC] [Abstract]

"Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation."
Immunogenetics 33:335-344(1991) [PubMed] [Europe PMC] [Abstract]

"Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype."
J. Exp. Med. 174:93-102(1991) [PubMed] [Europe PMC] [Abstract]

"Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46)."
Mol. Reprod. Dev. 34:107-113(1993) [PubMed] [Europe PMC] [Abstract]

"Post-translational modification and intracellular localization of a splice product of CD46 cloned from human testis: role of the intracellular domains in O-glycosylation."
Immunology 93:546-555(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis."
J. Infect. Dis. 181:1447-1449(2000) [PubMed] [Europe PMC] [Abstract]

"Characterization of the promoter region of the membrane cofactor protein (CD46) gene of the human complement system and comparison to a membrane cofactor protein-like genetic element."
J. Immunol. 151:4137-4146(1993) [PubMed] [Europe PMC] [Abstract]

"Homology of an acrosome-reacted sperm-specific antigen to CD46."
J. Pharmacobio-Dyn. 15:455-459(1992) [PubMed] [Europe PMC] [Abstract]

"Human non-lineage antigen, CD46 (HuLy-m5): purification and partial sequencing demonstrates structural homology with complement-regulating glycoproteins."
Immunogenetics 31:21-28(1990) [PubMed] [Europe PMC] [Abstract]

"Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus."
J. Virol. 67:6025-6032(1993) [PubMed] [Europe PMC] [Abstract]

"Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity."
J. Immunol. 147:3005-3011(1991) [PubMed] [Europe PMC] [Abstract]

"Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing."
Eur. J. Immunol. 22:1513-1518(1992) [PubMed] [Europe PMC] [Abstract]

"The human CD46 molecule is a receptor for measles virus (Edmonston strain)."
Cell 75:295-305(1993) [PubMed] [Europe PMC] [Abstract]

"Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46)."
Proc. Natl. Acad. Sci. U.S.A. 92:2303-2307(1995) [PubMed] [Europe PMC] [Abstract]

"Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus."
Proc. Natl. Acad. Sci. U.S.A. 92:2489-2493(1995) [PubMed] [Europe PMC] [Abstract]

"The N-glycan of the SCR 2 region is essential for membrane cofactor protein (CD46) to function as a measles virus receptor."
J. Virol. 70:4973-4977(1996) [PubMed] [Europe PMC] [Abstract]

"Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria."
Mol. Microbiol. 25:639-647(1997) [PubMed] [Europe PMC] [Abstract]

"Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory function."
J. Immunol. 161:3711-3718(1998) [PubMed] [Europe PMC] [Abstract]

"CD46 is a cellular receptor for human herpesvirus 6."
Cell 99:817-827(1999) [PubMed] [Europe PMC] [Abstract]

"Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation."
J. Immunol. 164:1839-1846(2000) [PubMed] [Europe PMC] [Abstract]

"CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation."
J. Immunol. 164:6091-6095(2000) [PubMed] [Europe PMC] [Abstract]

"SLAM (CDw150) is a cellular receptor for measles virus."
Nature 406:893-897(2000) [PubMed] [Europe PMC] [Abstract]

"Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence."
Cell. Microbiol. 3:133-143(2001) [PubMed] [Europe PMC] [Abstract]

"Human Herpesvirus 6 and Measles Virus employ distinct CD46 domains for receptor function."
J. Biol. Chem. 277:39112-39118(2002) [PubMed] [Europe PMC] [Abstract]

"CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae."
J. Cell Biol. 156:951-957(2002) [PubMed] [Europe PMC] [Abstract]

"Identification of the streptococcal M protein binding site on membrane cofactor protein (CD46)."
J. Immunol. 168:4585-4592(2002) [PubMed] [Europe PMC] [Abstract]

"Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa."
Mol. Reprod. Dev. 62:534-546(2002) [PubMed] [Europe PMC] [Abstract]

"Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46."
J. Biol. Chem. 278:25964-25969(2003) [PubMed] [Europe PMC] [Abstract]

"Down-regulation of CD46 by piliated Neisseria gonorrhoeae."
J. Exp. Med. 198:1313-1322(2003) [PubMed] [Europe PMC] [Abstract]

"Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46."
J. Virol. 77:4992-4999(2003) [PubMed] [Europe PMC] [Abstract]

"Adenovirus type 11 uses CD46 as a cellular receptor."
J. Virol. 77:9183-9191(2003) [PubMed] [Europe PMC] [Abstract]

"Familial haemolytic uraemic syndrome and an MCP mutation."
Lancet 362:1542-1547(2003) [PubMed] [Europe PMC] [Abstract]

"Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype."
Nature 421:388-392(2003) [PubMed] [Europe PMC] [Abstract]

"CD46 is a cellular receptor for group B adenoviruses."
Nat. Med. 9:1408-1412(2003) [PubMed] [Europe PMC] [Abstract]

"Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form."
Eur. J. Immunol. 34:2620-2629(2004) [PubMed] [Europe PMC] [Abstract]

"Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis."
J. Virol. 78:3897-3905(2004) [PubMed] [Europe PMC] [Abstract]

"The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3."
J. Virol. 78:4454-4462(2004) [PubMed] [Europe PMC] [Abstract]

"Localization of regions in CD46 that interact with adenovirus."
J. Virol. 79:7503-7513(2005) [PubMed] [Europe PMC] [Abstract]

"CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7."
J. Virol. 79:14429-14436(2005) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of two CD46 domains reveals an extended measles virus-binding surface."
EMBO J. 18:2911-2922(1999) [PubMed] [Europe PMC] [Abstract]

"Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome."
Proc. Natl. Acad. Sci. U.S.A. 100:12966-12971(2003) [PubMed] [Europe PMC] [Abstract]

"Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome."
Blood 108:1267-1279(2006) [PubMed] [Europe PMC] [Abstract]

"Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree."
Mol. Immunol. 43:1769-1775(2006) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
Hum. Mutat. 31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]