Lipase, Hormone Sensitive (LIPE)

HSL; LHS; Hormone Sensitive Lipase

SPN	V554
HGNC	6621
MGI	96790
PubMed	12364542
RGD	3010
UniProt	Q05469
Wiki	LIPE

LIPE) is an intracellular neutral lipase that is capable of hydrolyzing a variety of esters. The enzyme has a long and a short form. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.

LIPE is activated when the body needs to mobilize energy stores, and so responds positively to catecholamines, ACTH, and negatively to insulin. Previously, glucagon was thought to activate LIPE, however the removal of insulin's inhibitory effects ("cutting the brakes") is the source of activation. The lipolytic effect of glucagon in adipose tissue is minimal in humans.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV554Hu01	Recombinant Lipase, Hormone Sensitive (LIPE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV554Hu01	Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IP.
Antibodies	PAV554Hu01	Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IF.
Assay Kits	CLV554Hu01	CLIA Kit for Lipase, Hormone Sensitive (LIPE)	CLIA assay for Antigen Detection
Assay Kits	ELV554Hu01	ELISA Kit for Lipase, Hormone Sensitive (LIPE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV554Mu01	Recombinant Lipase, Hormone Sensitive (LIPE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV554Mu01	Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IP.
Antibodies	PAV554Mu01	Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IF.
Assay Kits	CLV554Mu01	CLIA Kit for Lipase, Hormone Sensitive (LIPE)	CLIA assay for Antigen Detection
Assay Kits	ELV554Mu01	ELISA Kit for Lipase, Hormone Sensitive (LIPE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV554Ra01	Recombinant Lipase, Hormone Sensitive (LIPE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV554Ra01	Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IP.
Antibodies	PAV554Ra01	Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IF.
Assay Kits	CLV554Ra01	CLIA Kit for Lipase, Hormone Sensitive (LIPE)	CLIA assay for Antigen Detection
Assay Kits	ELV554Ra01	ELISA Kit for Lipase, Hormone Sensitive (LIPE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV554Ca01	Recombinant Lipase, Hormone Sensitive (LIPE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV554Ca01	Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IP.
Antibodies	PAV554Ca01	Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IF.
Assay Kits	CLV554Ca01	CLIA Kit for Lipase, Hormone Sensitive (LIPE)	CLIA assay for Antigen Detection
Assay Kits	ELV554Ca01	ELISA Kit for Lipase, Hormone Sensitive (LIPE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV554Po01	Recombinant Lipase, Hormone Sensitive (LIPE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV554Po01	Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IP.
Antibodies	PAV554Po01	Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IF.
Assay Kits	CLV554Po01	CLIA Kit for Lipase, Hormone Sensitive (LIPE)	CLIA assay for Antigen Detection
Assay Kits	ELV554Po01	ELISA Kit for Lipase, Hormone Sensitive (LIPE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV554Bo01	Recombinant Lipase, Hormone Sensitive (LIPE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV554Bo01	Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IP.
Antibodies	PAV554Bo01	Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IF.
Assay Kits	CLV554Bo01	CLIA Kit for Lipase, Hormone Sensitive (LIPE)	CLIA assay for Antigen Detection
Assay Kits	ELV554Bo01	ELISA Kit for Lipase, Hormone Sensitive (LIPE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV554Rb01	Recombinant Lipase, Hormone Sensitive (LIPE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV554Rb01	Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IP.
Antibodies	PAV554Rb01	Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IF.
Assay Kits	CLV554Rb01	CLIA Kit for Lipase, Hormone Sensitive (LIPE)	CLIA assay for Antigen Detection
Assay Kits	ELV554Rb01	ELISA Kit for Lipase, Hormone Sensitive (LIPE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV554Mo01	Recombinant Lipase, Hormone Sensitive (LIPE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV554Mo01	Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IP.
Antibodies	PAV554Mo01	Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE)	WB; IHC; ICC; IF.
Assay Kits	CLV554Mo01	CLIA Kit for Lipase, Hormone Sensitive (LIPE)	CLIA assay for Antigen Detection
Assay Kits	ELV554Mo01	ELISA Kit for Lipase, Hormone Sensitive (LIPE)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium."
Proc. Natl. Acad. Sci. U.S.A. 90:4897-4901(1993) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase."
Genomics 35:441-447(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Association and insulin regulated translocation of hormone-sensitive lipase with PTRF."
Biochem. Biophys. Res. Commun. 350:657-661(2006) [PubMed] [Europe PMC] [Abstract]

"Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions."
FEBS J. 273:3381-3392(2006) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes."
N. Engl. J. Med. 370:2307-2315(2014) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]