Cluster Of Differentiation 52 (CD52)

CDW52; HE5; CAMPATH-1 Antigen; Cambridge pathology 1 antigen; Epididymal secretory protein E5; Human epididymis-specific protein 5

SPN	V551
HGNC	1804
MGI	1346088
PubMed	9593475
UniProt	P31358
Wiki	CD52

CD52 is a protein present on the surface of mature lymphocytes. It also is found in monocytes and dendritic cells. It is a glycosylphosphatidylinositol (GPI)--anchored antigen expressed on the all lymphocytes as well as within the male genital tract.The CAMPATH-1 family of monoclonal antibodies recognize an antigen expressed on human lymphocytes and monocytes. The antigen is an unusually good target for complement-mediated attack and, for this reason, the IgM antibody, CAMPATH-1M, has been widely used for removal of T lymphocytes from donor bone marrow to prevent graft-vs-host disease. Because the target antigen is expressed in most cases of lymphoid malignancy, serotherapy of lymphoma and leukemia with CAMPATH-1 antibodies has also been attempted.

Reference

"Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone."
Eur. J. Immunol. 21:1677-1684(1991) [PubMed] [Europe PMC] [Abstract]

"A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone."
Mol. Reprod. Dev. 34:8-15(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis."
Biochem. J. 293:633-640(1993) [PubMed] [Europe PMC] [Abstract]