Integrin Alpha V (ITGaV)

CD51; ITG-AV; MSK8; VNRA; Vitronectin Receptor,Alpha Polypeptide

SPN	V548
HGNC	6150
MGI	96608
PubMed	10965141
RGD	1310613
UniProt	P06756
Wiki	ITGAV

Integrin Alpha V encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.

The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.

Reference

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