Acetyl Coenzyme A Carboxylase Alpha (ACACa)

ACAC; ACC1; ACCA; ACAC; ACC2; ACCB; ACACB; ACACA; Acetyl CoA Carboxylase; Biotin carboxylase

SPN	V546
HGNC	84
MGI	108451
PubMed	22718502
RGD	621248
UniProt	Q13085
Wiki	ACACA

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes and in the chloroplasts of most plants and algae, whereas it is a large, multi-domain enzyme in the endoplasmic reticulum of most eukaryotes. The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. The human genome contains the genes for two different ACCs — ACACA and ACACB. In muscle cells, malonyl-CoA inhibits beta-oxidation.

Reference

"Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms."
Proc. Natl. Acad. Sci. U.S.A. 92:4011-4015(1995) [PubMed] [Europe PMC] [Abstract]

"Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5'-untranslated mRNA region."
Proc. Natl. Acad. Sci. U.S.A. 100:7515-7520(2003) [PubMed] [Europe PMC] [Abstract]

"Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility."
Carcinogenesis 25:2417-2424(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterisation of an N-terminal variant of acetyl-CoA carboxylase-alpha: expression in human tissues and evolutionary aspects."
Biochim. Biophys. Acta 1634:97-106(2003) [PubMed] [Europe PMC] [Abstract]

"Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes."
Genomics 85:71-84(2005) [PubMed] [Europe PMC] [Abstract]

, Submitted (JUL-2007) to UniProtKB

"BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains."
Oncogene 21:6729-6739(2002) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase."
J. Biol. Chem. 281:3172-3181(2006) [PubMed] [Europe PMC] [Abstract]

"ACCA phosphopeptide recognition by the BRCT repeats of BRCA1."
J. Mol. Biol. 359:973-982(2006) [PubMed] [Europe PMC] [Abstract]

"Acetyl-CoA carboxylase deficiency: an inborn error of de novo fatty acid synthesis."
N. Engl. J. Med. 305:465-466(1981) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of Spot 14, a modulator of fatty acid synthesis."
Proc. Natl. Acad. Sci. U.S.A. 107:18820-18825(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]