Integrin Alpha 5 (ITGa5)

CD49e; CD49-E; ITG-A5; FNRA; VLA5A; Fibronectin Receptor,Alpha Polypeptide; Integrin alpha-F; CD49 antigen-like family member E

SPN	V543
HGNC	6141
MGI	96604
PubMed	23686445
RGD	2925
UniProt	P08648
Wiki	ITGA5

Integrin alpha-5 is product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.Argraves et al. (1986) isolated cDNA clones coding for the alpha subunit from a placenta cDNA library. The cDNAs code for 229 amino acids from the C terminus of the alpha subunit. The deduced sequence has a hydrophobic region with properties characteristic of a membrane-spanning domain.

Reference

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