V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC)

C-Myc; BHLHE39; Myc Proto-Oncogene Protein; Class E basic helix-loop-helix protein 39; Transcription factor p64; Proto-oncogene c-Myc

SPN	V540
HGNC	7553
MGI	97250
PubMed	20956327
RGD	3130
UniProt	P01106
Wiki	Myc

Myc (cMyc) is a protooncogene, which is overexpressed in a wide range of human cancers. When it is specifically-mutated, or overexpressed, it increases cell proliferation and functions as an oncogene. Myc gene encodes for a transcription factor that regulates expression of 15% of all genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). Myc belongs to Myc family of transcription factors, which also includes N-Myc and L-Myc genes. Myc-family transcription factors contain the bHLH/LZ (basic Helix-Loop-Helix Leucine Zipper) domain.Myc protein is a transcription factor that activates expression of a great number of genes through binding on consensus sequences (Enhancer Box sequences (E-boxes)) and recruiting histone acetyltransferases (HATs).

Reference

"The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma."
Cell 34:779-787(1983) [PubMed] [Europe PMC] [Abstract]

"Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours."
EMBO J. 2:2375-2383(1983) [PubMed] [Europe PMC] [Abstract]

"Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29."
Nature 301:722-725(1983) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of cloned cDNA of human c-myc oncogene."
Nature 303:725-728(1983) [PubMed] [Europe PMC] [Abstract]

"Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma."
Nature 306:760-765(1983) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product."
Proc. Natl. Acad. Sci. U.S.A. 80:3642-3645(1983) [PubMed] [Europe PMC] [Abstract]

"Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma."
Nature 309:592-597(1984) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon."
EMBO J. 3:383-387(1984) [PubMed] [Europe PMC] [Abstract]

"Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc."
Gene 124:231-237(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas."
Mol. Cell. Biol. 6:3481-3489(1986) [PubMed] [Europe PMC] [Abstract]

"The pathogenesis of Burkitt's lymphoma."
Adv. Cancer Res. 55:133-270(1990) [PubMed] [Europe PMC] [Abstract]

"DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein."
Eur. J. Biochem. 206:595-603(1992) [PubMed] [Europe PMC] [Abstract]

"Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas."
Nat. Genet. 5:56-61(1993) [PubMed] [Europe PMC] [Abstract]

"Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62."
Proc. Natl. Acad. Sci. U.S.A. 90:3216-3220(1993) [PubMed] [Europe PMC] [Abstract]

"c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas."
J. Biol. Chem. 270:18961-18965(1995) [PubMed] [Europe PMC] [Abstract]

"c-Raf kinase binds to N-terminal domain of c-Myc."
FEBS Lett. 414:465-470(1997) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7."
EMBO J. 23:2116-2125(2004) [PubMed] [Europe PMC] [Abstract]

"Six lysine residues on c-Myc are direct substrates for acetylation by p300."
Biochem. Biophys. Res. Commun. 336:274-280(2005) [PubMed] [Europe PMC] [Abstract]

"c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I."
Nat. Cell Biol. 7:311-318(2005) [PubMed] [Europe PMC] [Abstract]

"PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation."
Oncogene 24:1982-1993(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Induction of pluripotent stem cells from adult human fibroblasts by defined factors."
Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]

"Fbw7 and Usp28 regulate myc protein stability in response to DNA damage."
Cell Cycle 6:2327-2331(2007) [PubMed] [Europe PMC] [Abstract]

"The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth."
Genes Dev. 21:537-551(2007) [PubMed] [Europe PMC] [Abstract]

"Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer."
Mol. Cancer Ther. 6:542-551(2007) [PubMed] [Europe PMC] [Abstract]

"The ubiquitin-specific protease USP28 is required for MYC stability."
Nat. Cell Biol. 9:765-774(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Tipping the balance: Cdk2 enables Myc to suppress senescence."
Cancer Res. 70:6687-6691(2010) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation."
Proc. Natl. Acad. Sci. U.S.A. 107:58-63(2010) [PubMed] [Europe PMC] [Abstract]

"Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells."
Genes Dev. 24:1236-1241(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells."
J. Clin. Invest. 122:859-872(2012) [PubMed] [Europe PMC] [Abstract]

"Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper."
J. Mol. Biol. 281:165-181(1998) [PubMed] [Europe PMC] [Abstract]