V-Jun Sarcoma Virus 17 Oncogene Homolog (JUN)

C-Jun; AP1; CJun; p39; Jun Oncogene; Proto-oncogene c-Jun; Activator protein 1; Transcription factor AP-1

SPN	V538
HGNC	6204
MGI	96646
PubMed	2577867
RGD	2943
UniProt	P05412
Wiki	C-jun

c-Jun is the name of a gene and protein which, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated can survive. This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Reference

"Structure and chromosomal localization of the functional intronless human JUN protooncogene."
Proc. Natl. Acad. Sci. U.S.A. 85:9148-9152(1988) [PubMed] [Europe PMC] [Abstract]

"Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1."
Science 238:1386-1392(1987) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity."
Cell 64:573-584(1991) [PubMed] [Europe PMC] [Abstract]

"c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif."
Nucleic Acids Res. 21:1289-1295(1993) [PubMed] [Europe PMC] [Abstract]

"Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade."
Proc. Natl. Acad. Sci. U.S.A. 93:10803-10808(1996) [PubMed] [Europe PMC] [Abstract]

"Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene."
J. Biol. Chem. 271:18231-18236(1996) [PubMed] [Europe PMC] [Abstract]

"A new group of conserved coactivators that increase the specificity of AP-1 transcription factors."
Nature 383:453-457(1996) [PubMed] [Europe PMC] [Abstract]

"Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription."
Nature 394:909-913(1998) [PubMed] [Europe PMC] [Abstract]

"SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1."
J. Biol. Chem. 274:11115-11124(1999) [PubMed] [Europe PMC] [Abstract]

"Role of the ATFa/JNK2 complex in Jun activation."
Oncogene 18:3491-3500(1999) [PubMed] [Europe PMC] [Abstract]

"Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity."
J. Biol. Chem. 275:38802-38812(2000) [PubMed] [Europe PMC] [Abstract]

"A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300."
EMBO J. 20:6095-6103(2001) [PubMed] [Europe PMC] [Abstract]

"Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions."
J. Biol. Chem. 277:34967-34977(2002) [PubMed] [Europe PMC] [Abstract]

"Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells."
Oncogene 23:8805-8814(2004) [PubMed] [Europe PMC] [Abstract]

"The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling."
Science 303:1374-1378(2004) [PubMed] [Europe PMC] [Abstract]

"Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation."
Mol. Cell. Biol. 27:2027-2036(2007) [PubMed] [Europe PMC] [Abstract]

"Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription."
Mol. Cell. Biol. 26:1770-1785(2006) [PubMed] [Europe PMC] [Abstract]

"Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells."
J. Biol. Chem. 282:32121-32127(2007) [PubMed] [Europe PMC] [Abstract]

"Activation of Polo-like kinase 3 by hypoxic stresses."
J. Biol. Chem. 283:25928-25935(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation."
Nat. Cell Biol. 12:963-972(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation."
Carcinogenesis 32:659-666(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells."
J. Clin. Invest. 122:859-872(2012) [PubMed] [Europe PMC] [Abstract]

"Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation."
EMBO J. 32:1556-1567(2013) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA."
Nature 373:257-261(1995) [PubMed] [Europe PMC] [Abstract]

"High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer."
J. Biol. Chem. 271:13663-13667(1996) [PubMed] [Europe PMC] [Abstract]