V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS)

HRAS1; K-Ras; N-Ras; RASH1; C-Bas/Has; H-Ras; Transforming protein p21

SPN	V536
HGNC	5173
MGI	96224
PubMed	15950068
RGD	2827
UniProt	P01112
Wiki	HRAS

RAS is a G protein (specifically a small GTPase): a regulatory GTP hydrolase that cycles between two conformations–an activated or inactivated form, respectively RAS-GTP and RAS-GDP.

H-Ras is well known as one of the essential components of Ras/Raf/MEK/ERK cascade, which is a critical prosurvival signaling mechanism in most eukaryotic cells. Ras targets Raf/MEK/ERK cascade by integrating and transmitting extracellular signals from growth factor receptors to Raf, leading to the propagation of signals to modulate a serious of cellular survival events. Apoptosis signal-regulating kinasel (ASK1) serves as a general mediator of cell death because it is responsive to a variety of death signals.

Reference

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Nature 302:33-37(1983) [PubMed] [Europe PMC] [Abstract]

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Science 220:1061-1063(1983) [PubMed] [Europe PMC] [Abstract]

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"Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus."
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Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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