Agrin (AGRN)
Agrin Proteoglycan
Agrin is a large proteoglycan whose best characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. This protein has nine domains homologous to protease inhibitors. It may also have functions in other tissues and during other stages of development.
It is major proteoglycan component in glomerular basement membrane and may play a role in the renal filtration and cell-matrix interactions.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ) is called the MuSK receptor (Muscle specific kinase).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V529Hu01 | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | MV529Hu22 | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| PV529Hu01 | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV529Hu | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V529Mu01 | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| PV529Mu01 | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V529Ra01 | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| PV529Ra01 | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Agrin (AGRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Agrin (AGRN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Agrin (AGRN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Agrin (AGRN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Agrin (AGRN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Agrin (AGRN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Agrin (AGRN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Agrin (AGRN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Agrin (AGRN) | CLIA assay for Antigen Detection |
Reference
"Primary structure and high expression of human agrin in basement membranes of adult lung and kidney."
Eur. J. Biochem. 254:123-128(1998) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"Agrin binds to the nerve-muscle basal lamina via laminin."
J. Cell Biol. 137:671-683(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein."
Mol. Cell. Neurosci. 17:208-225(2001) [PubMed] [Europe PMC] [Abstract]
"Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) in sperm."
Biochem. Biophys. Res. Commun. 342:522-528(2006) [PubMed] [Europe PMC] [Abstract]
Erratum
Biochem. Biophys. Res. Commun. 344:453-453(2006)
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Proteomics characterization of extracellular space components in the human aorta."
Mol. Cell. Proteomics 9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]
"Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)."
J. Biol. Chem. 286:40624-40630(2011) [PubMed] [Europe PMC] [Abstract]
"C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction."
Exp. Gerontol. 48:76-80(2013) [PubMed] [Europe PMC] [Abstract]
"Identification of an agrin mutation that causes congenital myasthenia and affects synapse function."
Am. J. Hum. Genet. 85:155-167(2009) [PubMed] [Europe PMC] [Abstract]
Erratum
Am. J. Hum. Genet. 85:536-536(2009)
"LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin."
Hum. Genet. 131:1123-1135(2012) [PubMed] [Europe PMC] [Abstract]
"Agrin mutations lead to a congenital myasthenic syndrome with distal muscle weakness and atrophy."
Brain 137:2429-2443(2014) [PubMed] [Europe PMC] [Abstract]