Pleiotrophin (PTN)

HARP; HBGF8; HBNF; NEGF1; Heparin Binding Growth Factor 8; Neurite Growth-Promoting Factor 1; Heparin Affin Regulatory Peptide; Heparin Binding Growth Associated Molecule

SPN	V523
HGNC	9630
MGI	97804
PubMed	23084748
RGD	3444
UniProt	P21246
Wiki	Pleiotrophin

Pleiotrophin was initially recognized as a neurite outgrowth-promoting factor present in rat brain around birth and as a mitogen toward fibroblasts isolated from bovine uterus tissue. Together with midkine these growth-factors constitute a family of secreted heparin-binding proteins now known as the Neurite Growth-promoting Factor (NEGF) family. During embryonic and early postnatal development, Pleiotrophin is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. Pleiotrophin is also expressed by several tumor cells and is thought to be involved in tumor angiogenesis. In the adult central nervous system.  Pleiotrophin is expressed in an activity-dependent manner in the hippocampus, where it can suppress long term potentiation induction.

Reference

"Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues."
Biochem. Biophys. Res. Commun. 173:246-251(1990) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity."
Science 250:1690-1694(1990) [PubMed] [Europe PMC] [Abstract]

"Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins."
Growth Factors 5:99-114(1991) [PubMed] [Europe PMC] [Abstract]

"Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene."
Biochemistry 31:12023-12028(1992) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant."
Biochem. Biophys. Res. Commun. 192:420-429(1993) [PubMed] [Europe PMC] [Abstract]

"Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1."
Biochem. Biophys. Res. Commun. 238:528-533(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: high interspecies homology."
Neurochem. Res. 15:435-439(1990) [PubMed] [Europe PMC] [Abstract]

"A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine."
J. Biol. Chem. 267:2582-2587(1992) [PubMed] [Europe PMC] [Abstract]

"Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma."
Arterioscler. Thromb. 13:1798-1805(1993) [PubMed] [Europe PMC] [Abstract]

"Comparison of the disulfide bond arrangements of human recombinant and bovine brain heparin binding neurite-promoting factors."
Biochem. Biophys. Res. Commun. 192:738-746(1993) [PubMed] [Europe PMC] [Abstract]

"Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin."
J. Biol. Chem. 276:16772-16779(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]