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Elastase 4 (ELA4)

CLCR; CTRC; Chymotrypsin C; Caldecrin

Elastase 4 isa member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. These human caldecrin isoforms, like the rat preproenzyme, are composed of a signal peptide of 16 amino acids, a propeptide of 13 amino acids, and a mature form of 239 amino acids. Both recombinant caldecrins, produced in a baculovirus expression system, showed the same chymotrypsin-type protease activity and hypocalcemic activity. The hypocalcemic activity of both caldecrin isoforms remained intact even after treatment with phenylmethylsulfonyl fluoride (PMSF) to abolish their protease activity.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV522Hu01 Recombinant Elastase 4 (ELA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV522Hu01 Monoclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IP.
PAV522Hu01 Polyclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IF.
Assay Kits CLV522Hu01 CLIA Kit for Elastase 4 (ELA4) CLIA assay for Antigen Detection
ELV522Hu01 ELISA Kit for Elastase 4 (ELA4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV522Mu01 Recombinant Elastase 4 (ELA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV522Mu01 Monoclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IP.
PAV522Mu01 Polyclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IF.
Assay Kits CLV522Mu01 CLIA Kit for Elastase 4 (ELA4) CLIA assay for Antigen Detection
ELV522Mu01 ELISA Kit for Elastase 4 (ELA4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV522Ra01 Recombinant Elastase 4 (ELA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV522Ra01 Monoclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IP.
PAV522Ra01 Polyclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IF.
Assay Kits CLV522Ra01 CLIA Kit for Elastase 4 (ELA4) CLIA assay for Antigen Detection
ELV522Ra01 ELISA Kit for Elastase 4 (ELA4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV522Ca01 Recombinant Elastase 4 (ELA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV522Ca01 Monoclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IP.
PAV522Ca01 Polyclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IF.
Assay Kits CLV522Ca01 CLIA Kit for Elastase 4 (ELA4) CLIA assay for Antigen Detection
ELV522Ca01 ELISA Kit for Elastase 4 (ELA4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV522Po01 Recombinant Elastase 4 (ELA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV522Po01 Monoclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IP.
PAV522Po01 Polyclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IF.
Assay Kits CLV522Po01 CLIA Kit for Elastase 4 (ELA4) CLIA assay for Antigen Detection
ELV522Po01 ELISA Kit for Elastase 4 (ELA4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV522Bo01 Recombinant Elastase 4 (ELA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV522Bo01 Monoclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IP.
PAV522Bo01 Polyclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IF.
Assay Kits CLV522Bo01 CLIA Kit for Elastase 4 (ELA4) CLIA assay for Antigen Detection
ELV522Bo01 ELISA Kit for Elastase 4 (ELA4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV522Rb01 Recombinant Elastase 4 (ELA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV522Rb01 Monoclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IP.
PAV522Rb01 Polyclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IF.
Assay Kits CLV522Rb01 CLIA Kit for Elastase 4 (ELA4) CLIA assay for Antigen Detection
ELV522Rb01 ELISA Kit for Elastase 4 (ELA4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV522Mo01 Recombinant Elastase 4 (ELA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV522Mo01 Monoclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IP.
PAV522Mo01 Polyclonal Antibody to Elastase 4 (ELA4) WB; IHC; ICC; IF.
Assay Kits CLV522Mo01 CLIA Kit for Elastase 4 (ELA4) CLIA assay for Antigen Detection
ELV522Mo01 ELISA Kit for Elastase 4 (ELA4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and expression of human caldecrin."
FEBS Lett. 386:26-28(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene."
J. Biochem. 123:546-554(1998) [PubMed] [Europe PMC] [Abstract]

"Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation."
J. Biol. Chem. 288:9848-9859(2013) [PubMed] [Europe PMC] [Abstract]

"Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis."
Hum. Genet. 123:83-91(2008) [PubMed] [Europe PMC] [Abstract]

"Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis."
Nat. Genet. 40:78-82(2008) [PubMed] [Europe PMC] [Abstract]

"Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan."
Pancreatology 9:287-292(2009) [PubMed] [Europe PMC] [Abstract]

"Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis."
Gut 62:653-654(2013) [PubMed] [Europe PMC] [Abstract]

"Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants."
Gut 62:1602-1606(2013) [PubMed] [Europe PMC] [Abstract]

"Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk."
Gut 62:1616-1624(2013) [PubMed] [Europe PMC] [Abstract]