Proopiomelanocortin (POMC)

POC; NPP; ProOMC; ACTH; Pro-OMC; Pro Opiomelanocortin; Corticotropin-lipotropin; Corticotropin; Adrenocorticotropic hormone

SPN	V521
HGNC	9201
MGI	97742
PubMed	10893429
RGD	3366
UniProt	P01189
Wiki	POMC

Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products.

Reference

"Isolation and structural organization of the human corticotropin-beta-lipotropin precursor gene."
FEBS Lett. 135:97-102(1981) [PubMed] [Europe PMC] [Abstract]

"The human pro-opiomelanocortin gene: organization, sequence, and interspersion with repetitive DNA."
DNA 1:133-143(1982) [PubMed] [Europe PMC] [Abstract]

"Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene."
Nucleic Acids Res. 11:6847-6858(1983) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Synthesis, cloning and primary structure of DNA complementary to mRNA for human pituitary pro-opiomelanocortin."
Bioorg. Khim. 13:562-564(1987) [PubMed] [Europe PMC] [Abstract]

"Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide."
Proc. Natl. Acad. Sci. U.S.A. 77:4890-4894(1980) [PubMed] [Europe PMC] [Abstract]

"Complete amino acid sequence of a human pituitary glycopeptide: an important maturation product of pro-opiomelanocortin."
Proc. Natl. Acad. Sci. U.S.A. 78:4236-4240(1981) [PubMed] [Europe PMC] [Abstract]

"Primary structure of the major human pituitary pro-opiomelanocortin NH2-terminal glycopeptide. Evidence for an aldosterone-stimulating activity."
J. Biol. Chem. 256:7977-7984(1981) [PubMed] [Europe PMC] [Abstract]

"The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation."
Biochem. Biophys. Res. Commun. 102:710-716(1981) [PubMed] [Europe PMC] [Abstract]

"Confirmation of the 1-20 amino acid sequence of human adrenocorticotrophin."
Biochem. J. 133:11-13(1973) [PubMed] [Europe PMC] [Abstract]

"On the structure of human corticotropin (adrenocorticotropic hormone)."
J. Biol. Chem. 236:2970-2974(1961) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone."
Nature New Biol. 235:114-115(1972) [PubMed] [Europe PMC] [Abstract]

"Synthesis of the human adrenal cortex hormone (alpha-h-ACTH) with a revised amino-acid sequence."
Helv. Chim. Acta 55:1243-1266(1972) [PubMed] [Europe PMC] [Abstract]

"Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase method."
J. Am. Chem. Soc. 95:1310-1315(1973) [PubMed] [Europe PMC] [Abstract]

"Primary structure of human beta-lipotropin."
Nature 260:622-624(1976) [PubMed] [Europe PMC] [Abstract]

"Structure of a melanocyte-stimulating hormone from the human pituitary gland."
Nature 184:167-169(1959)

"Primary structure and morphine-like activity of human beta-endorphin."
Can. J. Biochem. 55:666-670(1977) [PubMed] [Europe PMC] [Abstract]

"Gamma-endorphin and schizophrenia: amino acid composition of gamma-endorphin and nucleotide sequence of gamma-endorphin cDNA from pituitary glands of schizophrenic patients."
Brain Res. 376:29-37(1986) [PubMed] [Europe PMC] [Abstract]

"Alpha-amidated peptides derived from pro-opiomelanocortin in normal human pituitary."
Biochem. J. 250:781-788(1988) [PubMed] [Europe PMC] [Abstract]

"Reduced expression of a naturally deleted form of human proopiomelanocortin complementary deoxyribonucleic acid after transfection into Chinese hamster ovary cells."
Endocrinology 136:195-201(1995) [PubMed] [Europe PMC] [Abstract]

"Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans."
Nat. Genet. 19:155-157(1998) [PubMed] [Europe PMC] [Abstract]

"Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study."
Diabetes 54:2492-2496(2005) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteomic analysis of the human pituitary."
Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract]

"Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes."
J. Clin. Endocrinol. Metab. 83:3737-3741(1998) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity."
Int. J. Obes. Relat. Metab. Disord. 23:293-298(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular screening of the proopiomelanocortin (POMC) gene in Italian obese children: report of three new mutations."
Int. J. Obes. Relat. Metab. Disord. 25:61-67(2001) [PubMed] [Europe PMC] [Abstract]

"A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism."
Hum. Mol. Genet. 11:1997-2004(2002) [PubMed] [Europe PMC] [Abstract]