Secretory Leukocyte Peptidase Inhibitor (SLPI)

ALK1; ALP; MPI; BLPI; HUSI; HUSI-I; WAP4; WFDC4; Antileukoproteinase; Seminal proteinase inhibitor; Mucus proteinase inhibitor; WAP four-disulfide core domain protein 4

SPN	V520
HGNC	11092
MGI	109297
PubMed	18380788
RGD	621768
UniProt	P03973
Wiki	SLPI

Antileukoproteinase is secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity.Secretory leukocyte protease inhibitor (SLPI) is a highly cationic single-chain protein with eight intramolecular disulfide bonds. It is found in large quantities in bronchial, cervical, and nasal mucosa, saliva, and seminal fluids. SLPI inhibits human leukocyte elastase, human cathepsin G, human trypsin, neutrophil elastase, and mast cell chymase.

Reference

"Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus."
Eur. J. Biochem. 160:61-67(1986) [PubMed] [Europe PMC] [Abstract]

"Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases."
Nucleic Acids Res. 14:7883-7896(1986) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red sea turtle proteinase inhibitor."
FEBS Lett. 199:43-48(1986) [PubMed] [Europe PMC] [Abstract]

"Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase."
Proc. Natl. Acad. Sci. U.S.A. 83:6692-6696(1986) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor."
Biol. Chem. Hoppe-Seyler 372:13-21(1991) [PubMed] [Europe PMC] [Abstract]

"The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin."
EMBO J. 7:345-351(1988) [PubMed] [Europe PMC] [Abstract]