Glutathione Reductase (GR)
GSR; GLUR; GRD1; Glutathione reductase, mitochondrial
Glutathione reductase, also known as GSR or GR, is an enzyme (EC 1.8.1.7) that reduces glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant.
For every mole of oxidized glutathione (GSSG), one mole of NADPH is required to reduce GSSG to GSH. The enzyme forms a FAD bound homodimer. The glutathione reductase is conserved between all kingdoms. In bacteria, yeasts, and animals, one glutathione reductase gene is found; however, in plant genomes, two GR genes are encoded. Drosophila and Trypanosomes do not have any GR at all . In these organisms, glutathione reduction is performed by either the thioredoxin or the trypanothione system, respectively.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V518Hu01 | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | MV518Hu22 | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| PV518Hu01 | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV518Hu | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V518Mu01 | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| PV518Mu01 | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV518Mu | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V518Ra01 | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | MV518Ra21 | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| PV518Ra01 | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV518Ra | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Glutathione Reductase (GR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Glutathione Reductase (GR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Glutathione Reductase (GR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Glutathione Reductase (GR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Glutathione Reductase (GR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Glutathione Reductase (GR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Glutathione Reductase (GR) | CLIA assay for Antigen Detection |
Reference
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Eur. J. Biochem. 188:523-528(1990) [PubMed] [Europe PMC] [Abstract]
"Structural organization of the human glutathione reductase (GSR) gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence."
Biochem. Biophys. Res. Commun. 269:366-368(2000) [PubMed] [Europe PMC] [Abstract]
"Expression of glutathione reductase splice variants in human tissues."
Biochem. Genet. 48:816-821(2010) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Three-dimensional structure of glutathione reductase at 2-A resolution."
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"Refined structure of glutathione reductase at 1.54-A resolution."
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"Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor."
J. Biol. Chem. 271:8101-8107(1996) [PubMed] [Europe PMC] [Abstract]
"Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity."
Biochemistry 36:6437-6447(1997) [PubMed] [Europe PMC] [Abstract]
"Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers."
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