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Integrin Alpha 4 (ITGa4)

CD49d; CD49-D; ITG-A4; IA4; Alpha 4 Subunit Of VLA-4 Receptor; CD49 antigen-like family member D; Integrin alpha-IV

The integrin family includes cell surface receptors for extracellular matrix components as well as receptors involved in various aspects of leukocyte adhesion. The integrins generally consist of alpha-beta heterodimeric transmembrane glycoproteins in which the alpha subunit is noncovalently associated with the beta subunit.
Integrin, alpha 4 belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V517Mu01 Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
PV517Mu01 Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits KEV517Ra ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Alpha 4 (ITGa4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Alpha 4 (ITGa4) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Alpha 4 (ITGa4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Alpha 4 (ITGa4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Alpha 4 (ITGa4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Alpha 4 (ITGa4) CLIA assay for Antigen Detection

Reference

"The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function."
EMBO J. 8:1361-1368(1989) [PubMed] [Europe PMC] [Abstract]

"A single mRNA encodes the alpha 150 and alpha 80/70 forms of the alpha subunit of VLA4."
Eur. J. Immunol. 22:1099-1102(1992) [PubMed] [Europe PMC] [Abstract]

"Identification of two variants of the human integrin alpha 4 subunit."
Mol. Immunol. 32:1453-1454(1995) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the alpha 4 integrin gene promoter."
Proc. Natl. Acad. Sci. U.S.A. 88:4094-4098(1991) [PubMed] [Europe PMC] [Abstract]

"The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis."
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"Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage."
J. Biol. Chem. 267:1786-1791(1992) [PubMed] [Europe PMC] [Abstract]

"A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion."
J. Biol. Chem. 273:5955-5962(1998) [PubMed] [Europe PMC] [Abstract]

"Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses."
Nature 402:676-681(1999) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding."
J. Biol. Chem. 276:40903-40909(2001) [PubMed] [Europe PMC] [Abstract]

"JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation."
J. Cell Biol. 183:1159-1173(2008) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]