Microtubule Associated Protein 4 (MAP4)

SPN	V513
HGNC	6862
MGI	97178
PubMed	12123579
RGD	1564359
UniProt	P27816
Wiki	MAP4

Microtubule-associated protein 4is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules.

The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.

Reference

"A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences."
J. Biol. Chem. 266:21886-21896(1991) [PubMed] [Europe PMC] [Abstract]

"Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains."
Biochemistry 34:2289-2301(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]