Thymic Stromal Lymphopoietin (TSLP)

SPN	V512
HGNC	30743
MGI	1855696
PubMed	20146705
UniProt	Q969D9
Wiki	TSLP

The cytokine thymic stromal lymphopoietin (TSLP) drives immature B cell development in vitro and may regulate T helper type 2 responses.Thymic stromal lymphopoietin, also known as TSLP, is a human gene.This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c dendritic cells.

Alternative splicing of this gene results in two transcript variants. TSLP is an interleukin (IL)-7-like cytokine produced by epithelial cells and triggers dendritic cell-mediated Th2 type allergic inflammatory responses.

Reference

"Human thymic stromal lymphopoietin preferentially stimulates myeloid cells."
J. Immunol. 167:336-343(2001) [PubMed] [Europe PMC] [Abstract]

"Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation."
Leukemia 15:1286-1292(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

"The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide."
Mucosal Immunol. 8:49-56(2015) [PubMed] [Europe PMC] [Abstract]