Tetraspanin 30 (TSPAN30)

CD63; LAMP-3; ME491; MLA1; OMA81H; Melanoma 1 antigen; Granulophysin; Lysosomal-associated membrane protein 3; Ocular melanoma-associated antigen

SPN	V488
HGNC	1692
MGI	99529
PubMed	21962903
RGD	62080
UniProt	P08962
Wiki	CD63

CD63 antigen is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins.

Reference

"Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression."
Cancer Res. 48:2955-2962(1988) [PubMed] [Europe PMC] [Abstract]

"Characterization of three abundant mRNAs from human ovarian granulosa cells."
DNA Cell Biol. 9:479-485(1990) [PubMed] [Europe PMC] [Abstract]

"CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells."
J. Biol. Chem. 266:3239-3245(1991) [PubMed] [Europe PMC] [Abstract]

"An ocular melanoma-associated antigen. Molecular characterization."
Arch. Ophthalmol. 110:399-404(1992) [PubMed] [Europe PMC] [Abstract]

"Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences."
Biochem. Biophys. Res. Commun. 185:436-442(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin."
J. Clin. Invest. 91:1775-1782(1993) [PubMed] [Europe PMC] [Abstract]

"Isolation and amino terminal sequencing of a novel melanoma-associated antigen."
Arch. Biochem. Biophys. 242:540-548(1985) [PubMed] [Europe PMC] [Abstract]

"The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells."
Mol. Biol. Cell 11:1829-1843(2000) [PubMed] [Europe PMC] [Abstract]

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

"LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells."
Cytometry 61:62-68(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein."
EMBO J. 25:3934-3942(2006) [PubMed] [Europe PMC] [Abstract]

"Integral and associated lysosomal membrane proteins."
Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets."
Thromb. Res. 125:152-158(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin."
Blood 118:4265-4273(2011) [PubMed] [Europe PMC] [Abstract]

"The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis."
Dev. Cell 21:708-721(2011) [PubMed] [Europe PMC] [Abstract]

"Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo."
J. Biol. Chem. 288:19060-19071(2013) [PubMed] [Europe PMC] [Abstract]

"TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling."
Biochem. J. 459:565-576(2014) [PubMed] [Europe PMC] [Abstract]