Adenylate Cyclase Activating Polypeptide 1, Pituitary (ADCYAP1)

PACAP; PRP-48; Pituitary Adenylate Cyclase Activating Peptide

SPN	V486
HGNC	241
MGI	105094
PubMed	21109983
RGD	2037
UniProt	P18509
Wiki	ADCYAP1

Pituitary adenylate cyclase-activating peptide, adenylate cyclase-activating polypeptide 1. Mediated by adenylate cyclase-activating polypeptide 1 receptors, this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells.

Adenylate cyclase-activating polypeptide 1 not only is a hypophysiotropic hormone but also functions as a neurotransmitter and neuromodulator. In addition, it plays a role in paracrine and autocrine regulation of certain types of cells. This gene is composed of five exons. Exons 1 and 2 encode the 5' UTR and signal peptide, respectively; exon 4 encodes an adenylate cyclase-activating polypeptide 1-related peptide; and exon 5 encodes the mature peptide and 3' UTR.

Reference

"Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide."
DNA Cell Biol. 11:21-30(1992) [PubMed] [Europe PMC] [Abstract]

"Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene."
Biochim. Biophys. Acta 1129:199-206(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs."
Biochem. Biophys. Res. Commun. 166:81-89(1990) [PubMed] [Europe PMC] [Abstract]

"Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells."
Sci. Signal. 6:RA51-RA51(2013) [PubMed] [Europe PMC] [Abstract]

"Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy."
Biochemistry 32:5832-5841(1993) [PubMed] [Europe PMC] [Abstract]

"Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution."
Int. J. Pept. Protein Res. 40:456-464(1992) [PubMed] [Europe PMC] [Abstract]

"Conformation of a peptide ligand bound to its G-protein coupled receptor."
Nat. Struct. Biol. 8:161-165(2001) [PubMed] [Europe PMC] [Abstract]

"Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS."
Proc. Natl. Acad. Sci. U.S.A. 104:7875-7880(2007) [PubMed] [Europe PMC] [Abstract]

"Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes."
Hum. Mutat. 19:572-573(2002) [PubMed] [Europe PMC] [Abstract]