Glucokinase Regulatory Protein (GKRP)
GCKR; Glucokinase(hexokinase 4)regulator
The glucokinase regulatory protein (GKRP) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location of this key enzyme of glucose metabolism.GKRP is a 68 kD protein of 626 amino acids.
It is coded for by a 19 exon gene, GCKR, on the short arm of chromosome 2 (2p23). GKRP was discovered by Emile van Schaftingen and reported in 1989 Glucokinase (GK) in liver cells phosphorylates glucose, preparing it for incorporation into glycogen. During periods of ample glucose supply, most GK activity can be found in the peripheral cytoplasm where glycogen synthesis is occurring.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV468Hu01 | Recombinant Glucokinase Regulatory Protein (GKRP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV468Hu01 | Monoclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IP. |
| PAV468Hu01 | Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV468Hu01 | CLIA Kit for Glucokinase Regulatory Protein (GKRP) | CLIA assay for Antigen Detection |
| ELV468Hu01 | ELISA Kit for Glucokinase Regulatory Protein (GKRP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV468Mu01 | Recombinant Glucokinase Regulatory Protein (GKRP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV468Mu01 | Monoclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IP. |
| PAV468Mu01 | Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV468Mu01 | CLIA Kit for Glucokinase Regulatory Protein (GKRP) | CLIA assay for Antigen Detection |
| ELV468Mu01 | ELISA Kit for Glucokinase Regulatory Protein (GKRP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV468Ra01 | Recombinant Glucokinase Regulatory Protein (GKRP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV468Ra01 | Monoclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IP. |
| PAV468Ra01 | Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV468Ra01 | CLIA Kit for Glucokinase Regulatory Protein (GKRP) | CLIA assay for Antigen Detection |
| ELV468Ra01 | ELISA Kit for Glucokinase Regulatory Protein (GKRP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV468Ca01 | Recombinant Glucokinase Regulatory Protein (GKRP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV468Ca01 | Monoclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IP. |
| PAV468Ca01 | Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV468Ca01 | CLIA Kit for Glucokinase Regulatory Protein (GKRP) | CLIA assay for Antigen Detection |
| ELV468Ca01 | ELISA Kit for Glucokinase Regulatory Protein (GKRP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV468Po01 | Recombinant Glucokinase Regulatory Protein (GKRP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV468Po01 | Monoclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IP. |
| PAV468Po01 | Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV468Po01 | CLIA Kit for Glucokinase Regulatory Protein (GKRP) | CLIA assay for Antigen Detection |
| ELV468Po01 | ELISA Kit for Glucokinase Regulatory Protein (GKRP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV468Bo01 | Recombinant Glucokinase Regulatory Protein (GKRP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV468Bo01 | Monoclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IP. |
| PAV468Bo01 | Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV468Bo01 | CLIA Kit for Glucokinase Regulatory Protein (GKRP) | CLIA assay for Antigen Detection |
| ELV468Bo01 | ELISA Kit for Glucokinase Regulatory Protein (GKRP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV468Rb01 | Recombinant Glucokinase Regulatory Protein (GKRP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV468Rb01 | Monoclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IP. |
| PAV468Rb01 | Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV468Rb01 | CLIA Kit for Glucokinase Regulatory Protein (GKRP) | CLIA assay for Antigen Detection |
| ELV468Rb01 | ELISA Kit for Glucokinase Regulatory Protein (GKRP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV468Mo01 | Recombinant Glucokinase Regulatory Protein (GKRP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV468Mo01 | Monoclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IP. |
| PAV468Mo01 | Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV468Mo01 | CLIA Kit for Glucokinase Regulatory Protein (GKRP) | CLIA assay for Antigen Detection |
| ELV468Mo01 | ELISA Kit for Glucokinase Regulatory Protein (GKRP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization."
Mamm. Genome 6:532-536(1995) [PubMed] [Europe PMC] [Abstract]
"Organization of the human glucokinase regulator gene GCKR."
Genomics 49:137-142(1998) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase."
FEBS Lett. 456:332-338(1999) [PubMed] [Europe PMC] [Abstract]
"The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population."
Diabetes 57:2253-2257(2008) [PubMed] [Europe PMC] [Abstract]
"The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver."
Hum. Mol. Genet. 18:4081-4088(2009) [PubMed] [Europe PMC] [Abstract]
"Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase."
Proc. Natl. Acad. Sci. U.S.A. 110:10171-10176(2013) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of glucokinase regulatory protein."
Biochemistry 52:3523-3531(2013) [PubMed] [Europe PMC] [Abstract]
"Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations."
Diabetes 57:3112-3121(2008) [PubMed] [Europe PMC] [Abstract]