Major Histocompatibility Complex Class II Invariant Chain (MHCDG)
CD74; HLA-DG; HLADG; DHLAG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; Ia antigen-associated invariant chain; HLA-DR antigens-associated invariant chain
In addition to functioning as an MHC class II chaperone, Cd74 was required for B-cell development in mice. B cells from mice lacking Cd74 had a low response to T-independent type II antigen and could not proliferate after mice were injected with antigen. Study of cell surface markers showed a developmental arrest that prevented immature virgin B cells from becoming mature B cells in the periphery. This block was independent of MHC class II expression and was an intrinsic feature of B cells that correlated with the amount of Cd74. Using immunohistochemical and confocal microscopy analyses, Schori et al. (2007) showed that transgenic mice that weakly expressed the p41 Cd74 isoform on an MHC I-Ab genetic background recovered better from central nervous system (CNS) injuries than did wildtype mice.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV464Hu01 | Recombinant Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV464Hu01 | Monoclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IP. |
| PAV464Hu01 | Polyclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV464Hu01 | CLIA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | CLIA assay for Antigen Detection |
| ELV464Hu01 | ELISA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV464Mu01 | Recombinant Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV464Mu01 | Monoclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IP. |
| PAV464Mu01 | Polyclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV464Mu01 | CLIA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | CLIA assay for Antigen Detection |
| ELV464Mu01 | ELISA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV464Ra01 | Recombinant Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV464Ra01 | Monoclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IP. |
| PAV464Ra01 | Polyclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV464Ra01 | CLIA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | CLIA assay for Antigen Detection |
| ELV464Ra01 | ELISA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV464Ca01 | Recombinant Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV464Ca01 | Monoclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IP. |
| PAV464Ca01 | Polyclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV464Ca01 | CLIA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | CLIA assay for Antigen Detection |
| ELV464Ca01 | ELISA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV464Po01 | Recombinant Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV464Po01 | Monoclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IP. |
| PAV464Po01 | Polyclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV464Po01 | CLIA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | CLIA assay for Antigen Detection |
| ELV464Po01 | ELISA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV464Bo01 | Recombinant Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV464Bo01 | Monoclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IP. |
| PAV464Bo01 | Polyclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV464Bo01 | CLIA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | CLIA assay for Antigen Detection |
| ELV464Bo01 | ELISA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV464Rb01 | Recombinant Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV464Rb01 | Monoclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IP. |
| PAV464Rb01 | Polyclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV464Rb01 | CLIA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | CLIA assay for Antigen Detection |
| ELV464Rb01 | ELISA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV464Mo01 | Recombinant Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV464Mo01 | Monoclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IP. |
| PAV464Mo01 | Polyclonal Antibody to Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV464Mo01 | CLIA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | CLIA assay for Antigen Detection |
| ELV464Mo01 | ELISA Kit for Major Histocompatibility Complex Class II Invariant Chain (MHCDG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure."
Proc. Natl. Acad. Sci. U.S.A. 80:7395-7399(1983) [PubMed] [Europe PMC] [Abstract]
"The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity."
EMBO J. 3:869-872(1984) [PubMed] [Europe PMC] [Abstract]
"Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens."
Nucleic Acids Res. 13:8827-8841(1985) [PubMed] [Europe PMC] [Abstract]
"Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes."
Proc. Natl. Acad. Sci. U.S.A. 83:4484-4488(1986) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]