Defensin Beta 1 (DEFb1)
B-DF1; DEFB1; BD1; DEF-B1; DEFB101; HBD1
The underlying genes responsible for defensin production are highly polymorphic. Some aspects are conserved, however, the hallmarks of a beta-defensin are its small size, high density of cationic charge and six-cysteine-residue motif. Generally they are encoded by two-exon genes, where the first exon encodes for a hydrophobic leader sequence and the second for a peptide containing the cysteine motif.
There are three main (known) forms of mammalian defensins, alpha-defensins, beta-defensins, and theta-defensins. It is theorised that some of the pathology of cystic fibrosis arises from the inhibition of beta-defensin activity on the epithelial surfaces of the lungs and trachea due to higher salt content.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV460Hu01 | Recombinant Defensin Beta 1 (DEFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV460Hu01 | Monoclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IP. |
| PAV460Hu01 | Polyclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV460Hu01 | CLIA Kit for Defensin Beta 1 (DEFb1) | CLIA assay for Antigen Detection |
| ELV460Hu01 | ELISA Kit for Defensin Beta 1 (DEFb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV460Mu01 | Recombinant Defensin Beta 1 (DEFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV460Mu01 | Monoclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IP. |
| PAV460Mu01 | Polyclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV460Mu01 | CLIA Kit for Defensin Beta 1 (DEFb1) | CLIA assay for Antigen Detection |
| ELV460Mu01 | ELISA Kit for Defensin Beta 1 (DEFb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV460Ra01 | Recombinant Defensin Beta 1 (DEFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV460Ra01 | Monoclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IP. |
| PAV460Ra01 | Polyclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV460Ra01 | CLIA Kit for Defensin Beta 1 (DEFb1) | CLIA assay for Antigen Detection |
| ELV460Ra01 | ELISA Kit for Defensin Beta 1 (DEFb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV460Ca01 | Recombinant Defensin Beta 1 (DEFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV460Ca01 | Monoclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IP. |
| PAV460Ca01 | Polyclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV460Ca01 | CLIA Kit for Defensin Beta 1 (DEFb1) | CLIA assay for Antigen Detection |
| ELV460Ca01 | ELISA Kit for Defensin Beta 1 (DEFb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV460Po01 | Recombinant Defensin Beta 1 (DEFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV460Po01 | Monoclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IP. |
| PAV460Po01 | Polyclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV460Po01 | CLIA Kit for Defensin Beta 1 (DEFb1) | CLIA assay for Antigen Detection |
| ELV460Po01 | ELISA Kit for Defensin Beta 1 (DEFb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV460Bo01 | Recombinant Defensin Beta 1 (DEFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV460Bo01 | Monoclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IP. |
| PAV460Bo01 | Polyclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV460Bo01 | CLIA Kit for Defensin Beta 1 (DEFb1) | CLIA assay for Antigen Detection |
| ELV460Bo01 | ELISA Kit for Defensin Beta 1 (DEFb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV460Rb01 | Recombinant Defensin Beta 1 (DEFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV460Rb01 | Monoclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IP. |
| PAV460Rb01 | Polyclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV460Rb01 | CLIA Kit for Defensin Beta 1 (DEFb1) | CLIA assay for Antigen Detection |
| ELV460Rb01 | ELISA Kit for Defensin Beta 1 (DEFb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV460Mo01 | Recombinant Defensin Beta 1 (DEFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV460Mo01 | Monoclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IP. |
| PAV460Mo01 | Polyclonal Antibody to Defensin Beta 1 (DEFb1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV460Mo01 | CLIA Kit for Defensin Beta 1 (DEFb1) | CLIA assay for Antigen Detection |
| ELV460Mo01 | ELISA Kit for Defensin Beta 1 (DEFb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry."
Genomics 43:316-320(1997) [PubMed] [Europe PMC] [Abstract]
"Human airway epithelia express a beta-defensin."
Am. J. Respir. Cell Mol. Biol. 16:343-349(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"hBD-1: a novel beta-defensin from human plasma."
FEBS Lett. 368:331-335(1995) [PubMed] [Europe PMC] [Abstract]
"Chemical synthesis of beta-defensins and LEAP-1/hepcidin."
J. Pept. Res. 59:241-248(2002) [PubMed] [Europe PMC] [Abstract]
"The structure of human beta-defensin-1: new insights into structural properties of beta-defensins."
J. Biol. Chem. 276:39021-39026(2001) [PubMed] [Europe PMC] [Abstract]
"Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity."
Protein Sci. 10:2470-2479(2001) [PubMed] [Europe PMC] [Abstract]